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EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains
In neurodegenerative diseases proteins fold into amyloid structures with distinct conformations (strains) that are characteristic of different diseases. However, there is a need to rapidly identify amyloid conformations in situ. Here we use machine learning on the full information available in fluor...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915571/ https://www.ncbi.nlm.nih.gov/pubmed/36778268 http://dx.doi.org/10.1101/2023.02.01.526692 |