A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

BACKGROUND & AIMS: Hypoxia in the intestinal epithelium can be caused by acute ischemic events or conditions like Inflammatory Bowel Disease (IBD) where immune cell infiltration produces ‘inflammatory hypoxia’, a chronic condition that starves the mucosa of oxygen. Epithelial regeneration after...

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Detalles Bibliográficos
Autores principales: Rivera, Kristina R., Bliton, R. Jarrett, Burclaff, Joseph, Czerwinski, Michael J., Liu, Jintong, Trueblood, Jessica M., Hinesley, Caroline M., Breau, Keith A, Joshi, Shlok, Pozdin, Vladimir A., Yao, Ming, Ziegler, Amanda L., Blikslager, Anthony T., Daniele, Michael A., Magness, Scott T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915581/
https://www.ncbi.nlm.nih.gov/pubmed/36778265
http://dx.doi.org/10.1101/2023.01.31.524747

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