Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

The unique arginine dependencies of cancer cell proliferation and survival creates metabolic vulnerability. Here, we investigate the impact of extracellular arginine availability on DNA replication and genotoxic resistance. Using DNA combing assays, we find that when extracellular arginine is limite...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Chang, Kelso, Andrew A., Karamafrooz, Adak, Chen, Yi-Hsuan, Chen, Wei-Kai, Cheng, Chun-Ting, Qi, Yue, Gu, Long, Malkas, Linda, Kung, Hsing-Jien, Moldovan, George-Lucian, Ciccia, Alberto, Stark, Jeremy M., Ann, David K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915598/
https://www.ncbi.nlm.nih.gov/pubmed/36778247
http://dx.doi.org/10.1101/2023.01.31.526362

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