Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

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Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, thei...

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Detalles Bibliográficos
Autores principales: Chongsaritsinsuk, Joann, Steigmeyer, Alexandra D., Mahoney, Keira E., Rosenfeld, Mia A., Lucas, Taryn M., Ince, Deniz, Kearns, Fiona L., Battison, Alexandria S., Hollenhorst, Marie A., Shon, D. Judy, Tiemeyer, Katherine H., Attah, Victor, Kwon, Catherine, Bertozzi, Carolyn R., Ferracane, Michael J., Amaro, Rommie E., Malaker, Stacy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915616/
https://www.ncbi.nlm.nih.gov/pubmed/36778266
http://dx.doi.org/10.1101/2023.02.01.526488
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