Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily spread to cortical and subcortical structures and lead to isolated behavioral symptoms

Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are characterized by diffuse spread of alpha-synuclein (α-syn) throughout the brain. Patients with PDD and DLB have a neuropsychological pattern of deficits that include executive dysfunction, such as abnormalities in planning, t...

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Detalles Bibliográficos
Autores principales: Weber, Matthew A., Kerr, Gemma, Thangavel, Ramasamy, Conlon, Mackenzie M., Abdelmotilib, Hisham A., Halhouli, Oday, Zhang, Qiang, Geerling, Joel C., Narayanan, Nandakumar S., Aldridge, Georgina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915664/
https://www.ncbi.nlm.nih.gov/pubmed/36778400
http://dx.doi.org/10.1101/2023.01.31.526365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915664/
https://www.ncbi.nlm.nih.gov/pubmed/36778400
http://dx.doi.org/10.1101/2023.01.31.526365

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