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Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model

OBJECTIVES: The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the pathogenesis of several cancers, and can be targeted for therapeut...

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Detalles Bibliográficos
Autores principales:	Walcheck, Morgan T., Schwartz, Patrick B., Carrillo, Noah D., Matkowsky, Kristina A., Nukaya, Manabu, Bradfield, Christopher A., Ronnekleiv-Kelly, Sean M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915668/ https://www.ncbi.nlm.nih.gov/pubmed/36778364 http://dx.doi.org/10.1101/2023.02.01.526625

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