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CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft tissue sarcomas with limited treatment options, and novel effective therapeutic strategies are desperately needed. We observe anti-proliferative efficacy of genetic depletion or pharmacological inhibition using the clinicall...

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Detalles Bibliográficos
Autores principales:	Wang, Jiawan, Calizo, Ana, Zhang, Lindy, Pino, James C., Lyu, Yang, Pollard, Kai, Zhang, Xiaochun, Larsson, Alex T., Conniff, Eric, Llosa, Nicolas, Wood, David K., Largaespada, David A., Moody, Susan E., Gosline, Sara J., Hirbe, Angela C., Pratilas, Christine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915673/ https://www.ncbi.nlm.nih.gov/pubmed/36778419 http://dx.doi.org/10.1101/2023.02.02.526674

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