Cargando…

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft tissue sarcomas with limited treatment options, and novel effective therapeutic strategies are desperately needed. We observe anti-proliferative efficacy of genetic depletion or pharmacological inhibition using the clinicall...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jiawan, Calizo, Ana, Zhang, Lindy, Pino, James C., Lyu, Yang, Pollard, Kai, Zhang, Xiaochun, Larsson, Alex T., Conniff, Eric, Llosa, Nicolas, Wood, David K., Largaespada, David A., Moody, Susan E., Gosline, Sara J., Hirbe, Angela C., Pratilas, Christine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915673/ https://www.ncbi.nlm.nih.gov/pubmed/36778419 http://dx.doi.org/10.1101/2023.02.02.526674

Ejemplares similares

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors
por: Wang, Jiawan, et al.
Publicado: (2023)

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology
por: Larsson, Alex T, et al.
Publicado: (2023)

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor
por: Lemberg, Kathryn M., et al.
Publicado: (2020)

Special Issue: “Genomics and Models of Nerve Sheath Tumors”
por: Hirbe, Angela C., et al.
Publicado: (2020)

A clinically and genomically annotated nerve sheath tumor biospecimen repository
por: Pollard, Kai, et al.
Publicado: (2020)

MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
por: Borcherding, Dana C., et al.
Publicado: (2023)

Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma
por: Odeniyide, Patience, et al.
Publicado: (2022)

Correction: Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma
por: Odeniyide, Patience, et al.
Publicado: (2022)

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1
por: Banerjee, Jineta, et al.
Publicado: (2020)

Cdk6: At the interface of Rb and p53
por: Nebenfuehr, Sofie, et al.
Publicado: (2018)

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways
por: Rabik, Cara A., et al.
Publicado: (2020)

SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis
por: Morales, Liza D., et al.
Publicado: (2012)

TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death
por: Qin, Wenjing, et al.
Publicado: (2019)

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma
por: Schreck, Karisa C, et al.
Publicado: (2020)

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors
por: Williams, Kyle B., et al.
Publicado: (2020)

Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors
por: Hirbe, Angela C., et al.
Publicado: (2017)

Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives
por: Prudner, Bethany C, et al.
Publicado: (2019)

CDK4, pRB and E2F1: connected to insulin
por: Fajas, Lluis, et al.
Publicado: (2010)

Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates
por: Komori, Toshihisa
Publicado: (2013)

CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition
por: Kim, Sungsoo, et al.
Publicado: (2022)

Proteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16
por: Pedersen, Anna-Kathrine, et al.
Publicado: (2021)

Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling
por: Morales, Liza D., et al.
Publicado: (2014)

SUMOylation of Rb enhances its binding with CDK2 and phosphorylation at early G1 phase
por: Meng, Fengxi, et al.
Publicado: (2016)

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors()
por: Patel, Ami V., et al.
Publicado: (2016)

Chromosome 8 gain is associated with high-grade transformation in MPNST
por: Dehner, Carina, et al.
Publicado: (2021)

Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90
por: Zhao, Shuai, et al.
Publicado: (2021)

Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells
por: Li, Songyu, et al.
Publicado: (2020)

To Rb or not to Rb
por: Wells, William A.
Publicado: (2002)

Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68
por: Yaung, Stephanie J., et al.
Publicado: (2015)

Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma
por: Mattox, Austin K, et al.
Publicado: (2022)

p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
por: Brugarolas, James, et al.
Publicado: (1998)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb
por: Mi, Da, et al.
Publicado: (2013)

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma
por: Tsuda, H, et al.
Publicado: (2000)

Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells
por: Varma, Hemant, et al.
Publicado: (2007)

Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.
por: Schade, Amy E., et al.
Publicado: (2019)

RB expression confers sensitivity to CDK4/6 inhibitor–mediated radiosensitization across breast cancer subtypes
por: Pesch, Andrea M., et al.
Publicado: (2022)

Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway
por: Li, Jianxiong, et al.
Publicado: (2022)

The Regulatory Role of miR-107–Cdk6-Rb Pathway in Airway Smooth Muscle Cells in Asthma
por: Xiong, Yi, et al.
Publicado: (2023)

Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner
por: Kim, Su-Jung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_58aucg70g95e5kruc27r8kdloi