Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

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Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi’s sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically <5% contain lytic replicating virus. Because both...

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Detalles Bibliográficos
Autores principales: Olson, Annabel T., Kang, Yuqi, Ladha, Anushka M., Lim, Chuan Bian, Lagunoff, Michael, Gujral, Taran S., Geballe, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915688/
https://www.ncbi.nlm.nih.gov/pubmed/36778430
http://dx.doi.org/10.1101/2023.02.01.526589
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