A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug targets, we screened the Repurposing, Focused Rescue, and Accel...

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Detalles Bibliográficos
Autores principales: Maher, S. P., Bakowski, M. A., Vantaux, A., Flannery, E. L., Andolina, C., Gupta, M., Antonova-Koch, Y., Argomaniz, M., Cabrera-Mora, M., Campo, B., Chao, A. T., Chatterjee, A. K., Cheng, W. T., Cooper, C. A., Cottier, K., Galinski, M. R., Harupa-Chung, A., Ji, H., Joseph, S. B., Lenz, T., Lonardi, S., Matheson, J., Mikolajczak, S. A., Padin-Irizarry, V., Pan, K., Peneau, J., Prudhomme, J., Roesch, C., Ruberto, A. A., Sabnis, S. S., Saney, C. L., Sattabongkot, J., Sereshki, S., Suriyakan, S., Moeller, T., Ubalee, R., Wang, Y., Wasisakun, P., Yin, J., McNamara, C. W., Joyner, C. J., Nosten, F., Witkowski, B., Le Roch, K. G., Kyle, D. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915689/
https://www.ncbi.nlm.nih.gov/pubmed/36778461
http://dx.doi.org/10.1101/2023.01.31.526483

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