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Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in non-human species (1–3) and recently demonstrated to occur in rare instances from one human generation to the next (4). Here we investigated numtogenesis dynamics in humans in two ways. Fi...

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Detalles Bibliográficos
Autores principales:	Zhou, Weichen, Karan, Kalpita R., Gu, Wenjin, Klein, Hans-Ulrich, Sturm, Gabriel, De Jager, Philip L., Bennett, David A., Hirano, Michio, Picard, Martin, Mills, Ryan E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915708/ https://www.ncbi.nlm.nih.gov/pubmed/36778249 http://dx.doi.org/10.1101/2023.02.03.527065

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