Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

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Cystic fibrosis (CF) is one of the most prevalent lethal genetic diseases with over 2000 identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Pharmacological chaperones such as Lumacaftor (VX-809), Tezacaftor (VX-661) and Elexacaftor (VX-445) treat mutation-in...

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Detalles Bibliográficos
Autores principales: Kim, Minsoo, McDonald, Eli Fritz, Sabusap, Carleen Mae P., Timalsina, Bibek, Joshi, Disha, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Plate, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915750/
https://www.ncbi.nlm.nih.gov/pubmed/36778339
http://dx.doi.org/10.1101/2023.02.04.527134
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