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Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

Physical interactions between T cell receptors (TCRs) and mutation-derived tumour neoantigens (neoAg) presented by major histocompatibility class-I (MHC-I) enable sensitive and specific cytolysis of tumour cells. Adoptive transfer of neoAg-reactive T cells in patients is correlated with response to...

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Detalles Bibliográficos
Autores principales:	Finnigan, John P., Newman, Jenna H., Patskovsky, Yury, Patskovska, Larysa, Ishizuka, Andrew S., Lynn, Geoffrey M., Seder, Robert A., Krogsgaard, Michelle, Bhardwaj, Nina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915759/ https://www.ncbi.nlm.nih.gov/pubmed/36778273 http://dx.doi.org/10.21203/rs.3.rs-2531184/v1

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