Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

Mostrar otras versiones (1)

BACKGROUND: Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) and inhibition has shown therapeutic promise, likely through enhanced low-density lipoprotein receptor (LD...

Descripción completa

Detalles Bibliográficos
Autores principales: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N., Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R., Walley, Keith R., Standage, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915797/
https://www.ncbi.nlm.nih.gov/pubmed/36778250
http://dx.doi.org/10.21203/rs.3.rs-2521836/v1

Ejemplares similares

Ejemplares similares