Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. We here report results from the largest HCM genome-wide association study (GWAS) and multi-trait analysis (MTAG) including 5,900 HCM cases, 68,359 controls, and 36,083 UK...

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Autores principales: Tadros, Rafik, Zheng, Sean L, Grace, Christopher, Jordà, Paloma, Francis, Catherine, Jurgens, Sean J, Thomson, Kate L, Harper, Andrew R, Ormondroyd, Elizabeth, West, Dominique M, Xu, Xiao, Theotokis, Pantazis I, Buchan, Rachel J, McGurk, Kathryn A, Mazzarotto, Francesco, Boschi, Beatrice, Pelo, Elisabetta, Lee, Michael, Noseda, Michela, Varnava, Amanda, Vermeer, Alexa MC, Walsh, Roddy, Amin, Ahmad S, van Slegtenhorst, Marjon A, Roslin, Nicole, Strug, Lisa J, Salvi, Erika, Lanzani, Chiara, de Marvao, Antonio, Roberts, Jason D, Tremblay-Gravel, Maxime, Giraldeau, Genevieve, Cadrin-Tourigny, Julia, L'Allier, Philippe L, Garceau, Patrick, Talajic, Mario, Pinto, Yigal M, Rakowski, Harry, Pantazis, Antonis, Baksi, John, Halliday, Brian P, Prasad, Sanjay K, Barton, Paul JR, O'Regan, Declan P, Cook, Stuart A, de Boer, Rudolf A, Christiaans, Imke, Michels, Michelle, Kramer, Christopher M, Ho, Carolyn Y, Neubauer, Stefan, Matthews, Paul M, Wilde, Arthur A, Tardif, Jean-Claude, Olivotto, Iacopo, Adler, Arnon, Goel, Anuj, Ware, James S, Bezzina, Connie R, Watkins, Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915807/
https://www.ncbi.nlm.nih.gov/pubmed/36778260
http://dx.doi.org/10.1101/2023.01.28.23285147

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