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Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic Individuals

BACKGROUND: Genetic scores for late-onset Alzheimer’s disease (LOAD) have been associated with preclinical cognitive decline and biomarker variations. Compared with an overall polygenic risk score (PRS), a pathway-specific PRS (p-PRS) may be more appropriate in predicting a specific biomarker or cog...

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Detalles Bibliográficos
Autores principales:	Xu, Yuexuan, Vasiljevic, Eva, Deming, Yuetiva K., Jonaitis, Erin M., Koscik, Rebecca L., Van Hulle, Carol A., Lu, Qiongshi, Carboni, Margherita, Kollmorgen, Gwendlyn, Wild, Norbert, Carlsson, Cynthia M., Johnson, Sterling C., Zetterberg, Henrik, Blennow, Kaj, Engelman, Corinne D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915839/ https://www.ncbi.nlm.nih.gov/pubmed/36778431 http://dx.doi.org/10.1101/2023.01.30.23285142

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