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FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

BRAFV600E mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAFV600E drives tumorigenesis through constitutive downstream extracellular signal-regulated kinase (ERK) activation, but high-intensity ERK activation can also trigger tumor suppression. Whether and how oncogeni...

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Detalles Bibliográficos
Autores principales:	Gao, Chenxi, Ge, Huaibin, Kuan, Shih-Fan, Cai, Chunhui, Lu, Xinghua, Esni, Farzad, Schoen, Robert, Wang, Jing, Chu, Edward, Hu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915899/ https://www.ncbi.nlm.nih.gov/pubmed/36778401 http://dx.doi.org/10.21203/rs.3.rs-2531119/v1

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