Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis

Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this s...

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Autores principales: Sandlow, Sarah, Rai, Puja, Shum, Ann, Chen, Hannah, Arnold, Jeffrey, Jangi, Sushrut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915949/
https://www.ncbi.nlm.nih.gov/pubmed/36788790
http://dx.doi.org/10.14309/crj.0000000000000929
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author Sandlow, Sarah
Rai, Puja
Shum, Ann
Chen, Hannah
Arnold, Jeffrey
Jangi, Sushrut
author_facet Sandlow, Sarah
Rai, Puja
Shum, Ann
Chen, Hannah
Arnold, Jeffrey
Jangi, Sushrut
author_sort Sandlow, Sarah
collection PubMed
description Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this small molecule. We describe a unique case of biopsy-proven Kaposi sarcoma of the skin and colon in a patient with biologic-resistant ulcerative colitis after treatment with ozanimod for 2 months. Given the potential risk of malignancy associated with this agent, physicians should be aware of this rare adverse event.
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spelling pubmed-99159492023-02-13 Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis Sandlow, Sarah Rai, Puja Shum, Ann Chen, Hannah Arnold, Jeffrey Jangi, Sushrut ACG Case Rep J Case Report Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this small molecule. We describe a unique case of biopsy-proven Kaposi sarcoma of the skin and colon in a patient with biologic-resistant ulcerative colitis after treatment with ozanimod for 2 months. Given the potential risk of malignancy associated with this agent, physicians should be aware of this rare adverse event. Wolters Kluwer 2023-02-10 /pmc/articles/PMC9915949/ /pubmed/36788790 http://dx.doi.org/10.14309/crj.0000000000000929 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Sandlow, Sarah
Rai, Puja
Shum, Ann
Chen, Hannah
Arnold, Jeffrey
Jangi, Sushrut
Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title_full Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title_fullStr Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title_full_unstemmed Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title_short Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis
title_sort ozanimod-associated iatrogenic kaposi sarcoma in a patient with ulcerative colitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915949/
https://www.ncbi.nlm.nih.gov/pubmed/36788790
http://dx.doi.org/10.14309/crj.0000000000000929
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