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Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis
Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initia...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915951/ https://www.ncbi.nlm.nih.gov/pubmed/36788786 http://dx.doi.org/10.14309/crj.0000000000000986 |
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author | Youssef, Michael Sedarous, Mary Grin, Andrea Chung, Andrew Hookey, Lawrence |
author_facet | Youssef, Michael Sedarous, Mary Grin, Andrea Chung, Andrew Hookey, Lawrence |
author_sort | Youssef, Michael |
collection | PubMed |
description | Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initial presentation of GPA. The diagnosis was made based on radiological and pathological findings of acute pancreatitis in conjunction with positive anti-PR3 antibody which is strongly associated with GPA. Systemic vasculitides are rare but important to consider in cases of idiopathic acute pancreatitis. Early diagnosis and therapy allow for high rates of remission and improved survival rates. |
format | Online Article Text |
id | pubmed-9915951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-99159512023-02-13 Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis Youssef, Michael Sedarous, Mary Grin, Andrea Chung, Andrew Hookey, Lawrence ACG Case Rep J Case Report Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initial presentation of GPA. The diagnosis was made based on radiological and pathological findings of acute pancreatitis in conjunction with positive anti-PR3 antibody which is strongly associated with GPA. Systemic vasculitides are rare but important to consider in cases of idiopathic acute pancreatitis. Early diagnosis and therapy allow for high rates of remission and improved survival rates. Wolters Kluwer 2023-02-10 /pmc/articles/PMC9915951/ /pubmed/36788786 http://dx.doi.org/10.14309/crj.0000000000000986 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Youssef, Michael Sedarous, Mary Grin, Andrea Chung, Andrew Hookey, Lawrence Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title | Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title_full | Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title_fullStr | Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title_full_unstemmed | Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title_short | Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis |
title_sort | acute pancreatitis as a first presentation of granulomatosis with polyangiitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915951/ https://www.ncbi.nlm.nih.gov/pubmed/36788786 http://dx.doi.org/10.14309/crj.0000000000000986 |
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