TGF-Beta Induces Activin A Production in Dermal Fibroblasts Derived from Patients with Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a catastrophic, ultra-rare disease of heterotopic ossification caused by genetic defects in the ACVR1 gene. The mutant ACVR1 receptor, when triggered by an inflammatory process, leads to heterotopic ossification of the muscles and ligaments. Activin A h...

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Detalles Bibliográficos
Autores principales: de Ruiter, Ruben D., Wisse, Lisanne E., Schoenmaker, Ton, Yaqub, Maqsood, Sánchez-Duffhues, Gonzalo, Eekhoff, E. Marelise W., Micha, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916423/
https://www.ncbi.nlm.nih.gov/pubmed/36768622
http://dx.doi.org/10.3390/ijms24032299

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