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Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in persons with HIV (PWH) (HIV-NAFLD). It is unknown if HIV-NAFLD is associated with impairment in health-related quality of life (HRQOL). We examined HRQOL in PWH with and without NAFLD, compared HRQOL in HIV- versus primary...

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Autores principales: Gawrieh, Samer, Corey, Kathleen E., Lake, Jordan E., Samala, Niharika, Desai, Archita P., Debroy, Paula, Sjoquist, Julia A., Robison, Montreca, Tann, Mark, Akisik, Fatih, Bhamidipalli, Surya S., Saha, Chandan K., Zachary, Kimon, Robbins, Gregory K., Gupta, Samir K., Chung, Raymond T., Chalasani, Naga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916563/
https://www.ncbi.nlm.nih.gov/pubmed/36763643
http://dx.doi.org/10.1371/journal.pone.0279685
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author Gawrieh, Samer
Corey, Kathleen E.
Lake, Jordan E.
Samala, Niharika
Desai, Archita P.
Debroy, Paula
Sjoquist, Julia A.
Robison, Montreca
Tann, Mark
Akisik, Fatih
Bhamidipalli, Surya S.
Saha, Chandan K.
Zachary, Kimon
Robbins, Gregory K.
Gupta, Samir K.
Chung, Raymond T.
Chalasani, Naga
author_facet Gawrieh, Samer
Corey, Kathleen E.
Lake, Jordan E.
Samala, Niharika
Desai, Archita P.
Debroy, Paula
Sjoquist, Julia A.
Robison, Montreca
Tann, Mark
Akisik, Fatih
Bhamidipalli, Surya S.
Saha, Chandan K.
Zachary, Kimon
Robbins, Gregory K.
Gupta, Samir K.
Chung, Raymond T.
Chalasani, Naga
author_sort Gawrieh, Samer
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in persons with HIV (PWH) (HIV-NAFLD). It is unknown if HIV-NAFLD is associated with impairment in health-related quality of life (HRQOL). We examined HRQOL in PWH with and without NAFLD, compared HRQOL in HIV- versus primary NAFLD, and determined factors associated with HRQOL in these groups. Prospectively enrolled 200 PWH and 474 participants with primary NAFLD completed the Rand SF-36 assessment which measures 8 domains of HRQOL. Individual domain scores were used to create composite physical and mental component summary scores. Univariate and multivariate analyses determined variables associated with HRQOL in PWH and in HIV- and primary NAFLD. In PWH, 48% had HIV-NAFLD, 10.2% had clinically significant fibrosis, 99.5% were on antiretroviral therapy, and 96.5% had HIV RNA <200 copies/ml. There was no difference in HRQOL in PWH with or without NAFLD. Diabetes, non-Hispanic ethnicity, and nadir CD4 counts were independently associated with impaired HRQOL in PWH. In HIV-NAFLD, HRQOL did not differ between participants with or without clinically significant fibrosis. Participants with HIV-NAFLD compared to those with primary NAFLD were less frequently cisgender females, White, more frequently Hispanic, had lower BMI and lower frequency of obesity and diabetes. HRQOL of individuals with HIV-NAFLD was not significantly different from those with primary NAFLD. In conclusion, in virally suppressed PWH, HRQOL is not different between participants with or without HIV-NAFLD. HRQOL is not different between HIV-NAFLD and primary NAFLD.
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spelling pubmed-99165632023-02-11 Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus Gawrieh, Samer Corey, Kathleen E. Lake, Jordan E. Samala, Niharika Desai, Archita P. Debroy, Paula Sjoquist, Julia A. Robison, Montreca Tann, Mark Akisik, Fatih Bhamidipalli, Surya S. Saha, Chandan K. Zachary, Kimon Robbins, Gregory K. Gupta, Samir K. Chung, Raymond T. Chalasani, Naga PLoS One Research Article Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in persons with HIV (PWH) (HIV-NAFLD). It is unknown if HIV-NAFLD is associated with impairment in health-related quality of life (HRQOL). We examined HRQOL in PWH with and without NAFLD, compared HRQOL in HIV- versus primary NAFLD, and determined factors associated with HRQOL in these groups. Prospectively enrolled 200 PWH and 474 participants with primary NAFLD completed the Rand SF-36 assessment which measures 8 domains of HRQOL. Individual domain scores were used to create composite physical and mental component summary scores. Univariate and multivariate analyses determined variables associated with HRQOL in PWH and in HIV- and primary NAFLD. In PWH, 48% had HIV-NAFLD, 10.2% had clinically significant fibrosis, 99.5% were on antiretroviral therapy, and 96.5% had HIV RNA <200 copies/ml. There was no difference in HRQOL in PWH with or without NAFLD. Diabetes, non-Hispanic ethnicity, and nadir CD4 counts were independently associated with impaired HRQOL in PWH. In HIV-NAFLD, HRQOL did not differ between participants with or without clinically significant fibrosis. Participants with HIV-NAFLD compared to those with primary NAFLD were less frequently cisgender females, White, more frequently Hispanic, had lower BMI and lower frequency of obesity and diabetes. HRQOL of individuals with HIV-NAFLD was not significantly different from those with primary NAFLD. In conclusion, in virally suppressed PWH, HRQOL is not different between participants with or without HIV-NAFLD. HRQOL is not different between HIV-NAFLD and primary NAFLD. Public Library of Science 2023-02-10 /pmc/articles/PMC9916563/ /pubmed/36763643 http://dx.doi.org/10.1371/journal.pone.0279685 Text en © 2023 Gawrieh et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gawrieh, Samer
Corey, Kathleen E.
Lake, Jordan E.
Samala, Niharika
Desai, Archita P.
Debroy, Paula
Sjoquist, Julia A.
Robison, Montreca
Tann, Mark
Akisik, Fatih
Bhamidipalli, Surya S.
Saha, Chandan K.
Zachary, Kimon
Robbins, Gregory K.
Gupta, Samir K.
Chung, Raymond T.
Chalasani, Naga
Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title_full Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title_fullStr Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title_full_unstemmed Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title_short Non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
title_sort non-alcoholic fatty liver disease is not associated with impairment in health-related quality of life in virally suppressed persons with human immune deficiency virus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916563/
https://www.ncbi.nlm.nih.gov/pubmed/36763643
http://dx.doi.org/10.1371/journal.pone.0279685
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