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The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916577/ https://www.ncbi.nlm.nih.gov/pubmed/36768357 http://dx.doi.org/10.3390/ijms24032031 |
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author | Gorini, Francesca Ambrosio, Susanna Lania, Luigi Majello, Barbara Amente, Stefano |
author_facet | Gorini, Francesca Ambrosio, Susanna Lania, Luigi Majello, Barbara Amente, Stefano |
author_sort | Gorini, Francesca |
collection | PubMed |
description | The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level. |
format | Online Article Text |
id | pubmed-9916577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99165772023-02-11 The Intertwined Role of 8-oxodG and G4 in Transcription Regulation Gorini, Francesca Ambrosio, Susanna Lania, Luigi Majello, Barbara Amente, Stefano Int J Mol Sci Review The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level. MDPI 2023-01-19 /pmc/articles/PMC9916577/ /pubmed/36768357 http://dx.doi.org/10.3390/ijms24032031 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gorini, Francesca Ambrosio, Susanna Lania, Luigi Majello, Barbara Amente, Stefano The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title | The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title_full | The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title_fullStr | The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title_full_unstemmed | The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title_short | The Intertwined Role of 8-oxodG and G4 in Transcription Regulation |
title_sort | intertwined role of 8-oxodg and g4 in transcription regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916577/ https://www.ncbi.nlm.nih.gov/pubmed/36768357 http://dx.doi.org/10.3390/ijms24032031 |
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