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The Intertwined Role of 8-oxodG and G4 in Transcription Regulation

The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it...

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Autores principales: Gorini, Francesca, Ambrosio, Susanna, Lania, Luigi, Majello, Barbara, Amente, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916577/
https://www.ncbi.nlm.nih.gov/pubmed/36768357
http://dx.doi.org/10.3390/ijms24032031
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author Gorini, Francesca
Ambrosio, Susanna
Lania, Luigi
Majello, Barbara
Amente, Stefano
author_facet Gorini, Francesca
Ambrosio, Susanna
Lania, Luigi
Majello, Barbara
Amente, Stefano
author_sort Gorini, Francesca
collection PubMed
description The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level.
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spelling pubmed-99165772023-02-11 The Intertwined Role of 8-oxodG and G4 in Transcription Regulation Gorini, Francesca Ambrosio, Susanna Lania, Luigi Majello, Barbara Amente, Stefano Int J Mol Sci Review The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level. MDPI 2023-01-19 /pmc/articles/PMC9916577/ /pubmed/36768357 http://dx.doi.org/10.3390/ijms24032031 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gorini, Francesca
Ambrosio, Susanna
Lania, Luigi
Majello, Barbara
Amente, Stefano
The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title_full The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title_fullStr The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title_full_unstemmed The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title_short The Intertwined Role of 8-oxodG and G4 in Transcription Regulation
title_sort intertwined role of 8-oxodg and g4 in transcription regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916577/
https://www.ncbi.nlm.nih.gov/pubmed/36768357
http://dx.doi.org/10.3390/ijms24032031
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