Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu(7) Receptor Modulation Activity and Antipsychotic-Like Properties

Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu(7) NAMs, we synthesized a new compound library containing 103 members, which were examined for NAM mGlu(7) activity in the T-REx 293 cell line expressing a recombinan...

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Detalles Bibliográficos
Autores principales: Kaczorowska, Katarzyna, Stankiewicz, Anna, Bugno, Ryszard, Paluchowska, Maria H., Burnat, Grzegorz, Brański, Piotr, Cieślik, Paulina, Wierońska, Joanna M., Milik, Mariusz, Nowak, Mateusz, Przybyłowicz, Agnieszka, Kozioł, Aneta, Hogendorf, Agata, Hogendorf, Adam S., Kalinowska-Tłuścik, Justyna, Duszyńska, Beata, Pilc, Andrzej, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916658/
https://www.ncbi.nlm.nih.gov/pubmed/36768302
http://dx.doi.org/10.3390/ijms24031981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916658/
https://www.ncbi.nlm.nih.gov/pubmed/36768302
http://dx.doi.org/10.3390/ijms24031981

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