Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme

Mammalian purine nucleoside phosphorylase (PNP) is biologically active as a homotrimer, in which each monomer catalyzes a reaction independently of the others. To answer the question of why the native PNP forms a trimeric structure, we constructed, in silico and in vitro, the monomeric form of the e...

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Detalles Bibliográficos
Autores principales: Dyzma, Alicja, Wielgus-Kutrowska, Beata, Girstun, Agnieszka, Matošević, Zoe Jelić, Staroń, Krzysztof, Bertoša, Branimir, Trylska, Joanna, Bzowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916683/
https://www.ncbi.nlm.nih.gov/pubmed/36768477
http://dx.doi.org/10.3390/ijms24032157

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