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Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment
In this review we focus on the role of glutamine in control of cancer stem cell (CSC) fate. We first provide an overview of glutamine metabolism, and then summarize relevant studies investigating how glutamine metabolism modulates the CSC compartment, concentrating on solid tumors. We schematically...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916789/ https://www.ncbi.nlm.nih.gov/pubmed/36768660 http://dx.doi.org/10.3390/ijms24032337 |
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author | Pacifico, Francesco Leonardi, Antonio Crescenzi, Elvira |
author_facet | Pacifico, Francesco Leonardi, Antonio Crescenzi, Elvira |
author_sort | Pacifico, Francesco |
collection | PubMed |
description | In this review we focus on the role of glutamine in control of cancer stem cell (CSC) fate. We first provide an overview of glutamine metabolism, and then summarize relevant studies investigating how glutamine metabolism modulates the CSC compartment, concentrating on solid tumors. We schematically describe how glutamine in CSC contributes to several metabolic pathways, such as redox metabolic pathways, ATP production, non-essential aminoacids and nucleotides biosynthesis, and ammonia production. Furthermore, we show that glutamine metabolism is a key regulator of epigenetic modifications in CSC. Finally, we briefly discuss how cancer-associated fibroblasts, adipocytes, and senescent cells in the tumor microenvironment may indirectly influence CSC fate by modulating glutamine availability. We aim to highlight the complexity of glutamine’s role in CSC, which supports our knowledge about metabolic heterogeneity within the CSC population. |
format | Online Article Text |
id | pubmed-9916789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99167892023-02-11 Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment Pacifico, Francesco Leonardi, Antonio Crescenzi, Elvira Int J Mol Sci Review In this review we focus on the role of glutamine in control of cancer stem cell (CSC) fate. We first provide an overview of glutamine metabolism, and then summarize relevant studies investigating how glutamine metabolism modulates the CSC compartment, concentrating on solid tumors. We schematically describe how glutamine in CSC contributes to several metabolic pathways, such as redox metabolic pathways, ATP production, non-essential aminoacids and nucleotides biosynthesis, and ammonia production. Furthermore, we show that glutamine metabolism is a key regulator of epigenetic modifications in CSC. Finally, we briefly discuss how cancer-associated fibroblasts, adipocytes, and senescent cells in the tumor microenvironment may indirectly influence CSC fate by modulating glutamine availability. We aim to highlight the complexity of glutamine’s role in CSC, which supports our knowledge about metabolic heterogeneity within the CSC population. MDPI 2023-01-25 /pmc/articles/PMC9916789/ /pubmed/36768660 http://dx.doi.org/10.3390/ijms24032337 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pacifico, Francesco Leonardi, Antonio Crescenzi, Elvira Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title | Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title_full | Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title_fullStr | Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title_full_unstemmed | Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title_short | Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment |
title_sort | glutamine metabolism in cancer stem cells: a complex liaison in the tumor microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916789/ https://www.ncbi.nlm.nih.gov/pubmed/36768660 http://dx.doi.org/10.3390/ijms24032337 |
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