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Eosinophilic Fasciitis: Current and Remaining Challenges
Eosinophilic fasciitis (EF), defined as diffuse fasciitis with eosinophilia by Shulman in 1974, is a disease with unknown etiology and whose pathogenesis is still being researched. The diagnosis is based on the clinical aspects (skin induration with an “orange peel” appearance), the lab results (eos...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916848/ https://www.ncbi.nlm.nih.gov/pubmed/36768300 http://dx.doi.org/10.3390/ijms24031982 |
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author | Mazilu, Diana Boltașiu (Tătaru), Laura Alina Mardale, Denise-Ani Bijă, Maria Silviana Ismail, Sermina Zanfir, Violeta Negoi, Florentina Balanescu, Andra Rodica |
author_facet | Mazilu, Diana Boltașiu (Tătaru), Laura Alina Mardale, Denise-Ani Bijă, Maria Silviana Ismail, Sermina Zanfir, Violeta Negoi, Florentina Balanescu, Andra Rodica |
author_sort | Mazilu, Diana |
collection | PubMed |
description | Eosinophilic fasciitis (EF), defined as diffuse fasciitis with eosinophilia by Shulman in 1974, is a disease with unknown etiology and whose pathogenesis is still being researched. The diagnosis is based on the clinical aspects (skin induration with an “orange peel” appearance), the lab results (eosinophilia, increased inflammatory markers), the skin biopsy with the pathognomonic histopathological result, as well as the typical MRI changes. The treatment includes glucocorticoids and immunosuppressive drugs. Due to severe refractory cases, the treatment remains a challenge. EF is still a disease with potential for further research. |
format | Online Article Text |
id | pubmed-9916848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99168482023-02-11 Eosinophilic Fasciitis: Current and Remaining Challenges Mazilu, Diana Boltașiu (Tătaru), Laura Alina Mardale, Denise-Ani Bijă, Maria Silviana Ismail, Sermina Zanfir, Violeta Negoi, Florentina Balanescu, Andra Rodica Int J Mol Sci Review Eosinophilic fasciitis (EF), defined as diffuse fasciitis with eosinophilia by Shulman in 1974, is a disease with unknown etiology and whose pathogenesis is still being researched. The diagnosis is based on the clinical aspects (skin induration with an “orange peel” appearance), the lab results (eosinophilia, increased inflammatory markers), the skin biopsy with the pathognomonic histopathological result, as well as the typical MRI changes. The treatment includes glucocorticoids and immunosuppressive drugs. Due to severe refractory cases, the treatment remains a challenge. EF is still a disease with potential for further research. MDPI 2023-01-19 /pmc/articles/PMC9916848/ /pubmed/36768300 http://dx.doi.org/10.3390/ijms24031982 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mazilu, Diana Boltașiu (Tătaru), Laura Alina Mardale, Denise-Ani Bijă, Maria Silviana Ismail, Sermina Zanfir, Violeta Negoi, Florentina Balanescu, Andra Rodica Eosinophilic Fasciitis: Current and Remaining Challenges |
title | Eosinophilic Fasciitis: Current and Remaining Challenges |
title_full | Eosinophilic Fasciitis: Current and Remaining Challenges |
title_fullStr | Eosinophilic Fasciitis: Current and Remaining Challenges |
title_full_unstemmed | Eosinophilic Fasciitis: Current and Remaining Challenges |
title_short | Eosinophilic Fasciitis: Current and Remaining Challenges |
title_sort | eosinophilic fasciitis: current and remaining challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916848/ https://www.ncbi.nlm.nih.gov/pubmed/36768300 http://dx.doi.org/10.3390/ijms24031982 |
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