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Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections,...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916856/ https://www.ncbi.nlm.nih.gov/pubmed/36768752 http://dx.doi.org/10.3390/ijms24032419 |
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author | Perez-Florido, Javier Casimiro-Soriguer, Carlos S. Ortuño, Francisco Fernandez-Rueda, Jose L. Aguado, Andrea Lara, María Riazzo, Cristina Rodriguez-Iglesias, Manuel A. Camacho-Martinez, Pedro Merino-Diaz, Laura Pupo-Ledo, Inmaculada de Salazar, Adolfo Viñuela, Laura Fuentes, Ana Chueca, Natalia García, Federico Dopazo, Joaquín Lepe, Jose A. |
author_facet | Perez-Florido, Javier Casimiro-Soriguer, Carlos S. Ortuño, Francisco Fernandez-Rueda, Jose L. Aguado, Andrea Lara, María Riazzo, Cristina Rodriguez-Iglesias, Manuel A. Camacho-Martinez, Pedro Merino-Diaz, Laura Pupo-Ledo, Inmaculada de Salazar, Adolfo Viñuela, Laura Fuentes, Ana Chueca, Natalia García, Federico Dopazo, Joaquín Lepe, Jose A. |
author_sort | Perez-Florido, Javier |
collection | PubMed |
description | Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity. |
format | Online Article Text |
id | pubmed-9916856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99168562023-02-11 Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia Perez-Florido, Javier Casimiro-Soriguer, Carlos S. Ortuño, Francisco Fernandez-Rueda, Jose L. Aguado, Andrea Lara, María Riazzo, Cristina Rodriguez-Iglesias, Manuel A. Camacho-Martinez, Pedro Merino-Diaz, Laura Pupo-Ledo, Inmaculada de Salazar, Adolfo Viñuela, Laura Fuentes, Ana Chueca, Natalia García, Federico Dopazo, Joaquín Lepe, Jose A. Int J Mol Sci Article Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity. MDPI 2023-01-26 /pmc/articles/PMC9916856/ /pubmed/36768752 http://dx.doi.org/10.3390/ijms24032419 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Perez-Florido, Javier Casimiro-Soriguer, Carlos S. Ortuño, Francisco Fernandez-Rueda, Jose L. Aguado, Andrea Lara, María Riazzo, Cristina Rodriguez-Iglesias, Manuel A. Camacho-Martinez, Pedro Merino-Diaz, Laura Pupo-Ledo, Inmaculada de Salazar, Adolfo Viñuela, Laura Fuentes, Ana Chueca, Natalia García, Federico Dopazo, Joaquín Lepe, Jose A. Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title_full | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title_fullStr | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title_full_unstemmed | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title_short | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia |
title_sort | detection of high level of co-infection and the emergence of novel sars cov-2 delta-omicron and omicron-omicron recombinants in the epidemiological surveillance of andalusia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916856/ https://www.ncbi.nlm.nih.gov/pubmed/36768752 http://dx.doi.org/10.3390/ijms24032419 |
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