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Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia

Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections,...

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Autores principales: Perez-Florido, Javier, Casimiro-Soriguer, Carlos S., Ortuño, Francisco, Fernandez-Rueda, Jose L., Aguado, Andrea, Lara, María, Riazzo, Cristina, Rodriguez-Iglesias, Manuel A., Camacho-Martinez, Pedro, Merino-Diaz, Laura, Pupo-Ledo, Inmaculada, de Salazar, Adolfo, Viñuela, Laura, Fuentes, Ana, Chueca, Natalia, García, Federico, Dopazo, Joaquín, Lepe, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916856/
https://www.ncbi.nlm.nih.gov/pubmed/36768752
http://dx.doi.org/10.3390/ijms24032419
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author Perez-Florido, Javier
Casimiro-Soriguer, Carlos S.
Ortuño, Francisco
Fernandez-Rueda, Jose L.
Aguado, Andrea
Lara, María
Riazzo, Cristina
Rodriguez-Iglesias, Manuel A.
Camacho-Martinez, Pedro
Merino-Diaz, Laura
Pupo-Ledo, Inmaculada
de Salazar, Adolfo
Viñuela, Laura
Fuentes, Ana
Chueca, Natalia
García, Federico
Dopazo, Joaquín
Lepe, Jose A.
author_facet Perez-Florido, Javier
Casimiro-Soriguer, Carlos S.
Ortuño, Francisco
Fernandez-Rueda, Jose L.
Aguado, Andrea
Lara, María
Riazzo, Cristina
Rodriguez-Iglesias, Manuel A.
Camacho-Martinez, Pedro
Merino-Diaz, Laura
Pupo-Ledo, Inmaculada
de Salazar, Adolfo
Viñuela, Laura
Fuentes, Ana
Chueca, Natalia
García, Federico
Dopazo, Joaquín
Lepe, Jose A.
author_sort Perez-Florido, Javier
collection PubMed
description Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity.
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spelling pubmed-99168562023-02-11 Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia Perez-Florido, Javier Casimiro-Soriguer, Carlos S. Ortuño, Francisco Fernandez-Rueda, Jose L. Aguado, Andrea Lara, María Riazzo, Cristina Rodriguez-Iglesias, Manuel A. Camacho-Martinez, Pedro Merino-Diaz, Laura Pupo-Ledo, Inmaculada de Salazar, Adolfo Viñuela, Laura Fuentes, Ana Chueca, Natalia García, Federico Dopazo, Joaquín Lepe, Jose A. Int J Mol Sci Article Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity. MDPI 2023-01-26 /pmc/articles/PMC9916856/ /pubmed/36768752 http://dx.doi.org/10.3390/ijms24032419 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perez-Florido, Javier
Casimiro-Soriguer, Carlos S.
Ortuño, Francisco
Fernandez-Rueda, Jose L.
Aguado, Andrea
Lara, María
Riazzo, Cristina
Rodriguez-Iglesias, Manuel A.
Camacho-Martinez, Pedro
Merino-Diaz, Laura
Pupo-Ledo, Inmaculada
de Salazar, Adolfo
Viñuela, Laura
Fuentes, Ana
Chueca, Natalia
García, Federico
Dopazo, Joaquín
Lepe, Jose A.
Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title_full Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title_fullStr Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title_full_unstemmed Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title_short Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
title_sort detection of high level of co-infection and the emergence of novel sars cov-2 delta-omicron and omicron-omicron recombinants in the epidemiological surveillance of andalusia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916856/
https://www.ncbi.nlm.nih.gov/pubmed/36768752
http://dx.doi.org/10.3390/ijms24032419
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