The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation

Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomar...

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Autores principales: Cánovas-Cervera, Irene, Nacher-Sendra, Elena, Osca-Verdegal, Rebeca, Dolz-Andrés, Enric, Beltrán-García, Jesús, Rodríguez-Gimillo, María, Ferrando-Sánchez, Carolina, Carbonell, Nieves, García-Giménez, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916911/
https://www.ncbi.nlm.nih.gov/pubmed/36768905
http://dx.doi.org/10.3390/ijms24032582
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author Cánovas-Cervera, Irene
Nacher-Sendra, Elena
Osca-Verdegal, Rebeca
Dolz-Andrés, Enric
Beltrán-García, Jesús
Rodríguez-Gimillo, María
Ferrando-Sánchez, Carolina
Carbonell, Nieves
García-Giménez, José Luis
author_facet Cánovas-Cervera, Irene
Nacher-Sendra, Elena
Osca-Verdegal, Rebeca
Dolz-Andrés, Enric
Beltrán-García, Jesús
Rodríguez-Gimillo, María
Ferrando-Sánchez, Carolina
Carbonell, Nieves
García-Giménez, José Luis
author_sort Cánovas-Cervera, Irene
collection PubMed
description Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K/AKT/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore.
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spelling pubmed-99169112023-02-11 The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation Cánovas-Cervera, Irene Nacher-Sendra, Elena Osca-Verdegal, Rebeca Dolz-Andrés, Enric Beltrán-García, Jesús Rodríguez-Gimillo, María Ferrando-Sánchez, Carolina Carbonell, Nieves García-Giménez, José Luis Int J Mol Sci Review Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K/AKT/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore. MDPI 2023-01-30 /pmc/articles/PMC9916911/ /pubmed/36768905 http://dx.doi.org/10.3390/ijms24032582 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cánovas-Cervera, Irene
Nacher-Sendra, Elena
Osca-Verdegal, Rebeca
Dolz-Andrés, Enric
Beltrán-García, Jesús
Rodríguez-Gimillo, María
Ferrando-Sánchez, Carolina
Carbonell, Nieves
García-Giménez, José Luis
The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title_full The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title_fullStr The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title_full_unstemmed The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title_short The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
title_sort intricate role of non-coding rnas in sepsis-associated disseminated intravascular coagulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916911/
https://www.ncbi.nlm.nih.gov/pubmed/36768905
http://dx.doi.org/10.3390/ijms24032582
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