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Gut Microbiome Proteomics in Food Allergies
Food allergies (FA) have dramatically increased in recent years, particularly in developed countries. It is currently well-established that food tolerance requires the strict maintenance of a specific microbial consortium in the gastrointestinal (GI) tract microbiome as alterations in the gut microb...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917015/ https://www.ncbi.nlm.nih.gov/pubmed/36768555 http://dx.doi.org/10.3390/ijms24032234 |
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author | Abril, Ana G. Carrera, Mónica Sánchez-Pérez, Ángeles Villa, Tomás G. |
author_facet | Abril, Ana G. Carrera, Mónica Sánchez-Pérez, Ángeles Villa, Tomás G. |
author_sort | Abril, Ana G. |
collection | PubMed |
description | Food allergies (FA) have dramatically increased in recent years, particularly in developed countries. It is currently well-established that food tolerance requires the strict maintenance of a specific microbial consortium in the gastrointestinal (GI) tract microbiome as alterations in the gut microbiota can lead to dysbiosis, causing inflammation and pathogenic intestinal conditions that result in the development of FA. Although there is currently not enough knowledge to fully understand how the interactions between gut microbiota, host responses and the environment cause food allergies, recent advances in ‘-omics’ technologies (i.e., proteomics, genomics, metabolomics) and in approaches involving systems biology suggest future headways that would finally allow the scientific understanding of the relationship between gut microbiome and FA. This review summarizes the current knowledge in the field of FA and insights into the future advances that will be achieved by applying proteomic techniques to study the GI tract microbiome in the field of FA and their medical treatment. Metaproteomics, a proteomics experimental approach of great interest in the study of GI tract microbiota, aims to analyze and identify all the proteins in complex environmental microbial communities; with shotgun proteomics, which uses liquid chromatography (LC) for separation and tandem mass spectrometry (MS/MS) for analysis, as it is the most promising technique in this field. |
format | Online Article Text |
id | pubmed-9917015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99170152023-02-11 Gut Microbiome Proteomics in Food Allergies Abril, Ana G. Carrera, Mónica Sánchez-Pérez, Ángeles Villa, Tomás G. Int J Mol Sci Review Food allergies (FA) have dramatically increased in recent years, particularly in developed countries. It is currently well-established that food tolerance requires the strict maintenance of a specific microbial consortium in the gastrointestinal (GI) tract microbiome as alterations in the gut microbiota can lead to dysbiosis, causing inflammation and pathogenic intestinal conditions that result in the development of FA. Although there is currently not enough knowledge to fully understand how the interactions between gut microbiota, host responses and the environment cause food allergies, recent advances in ‘-omics’ technologies (i.e., proteomics, genomics, metabolomics) and in approaches involving systems biology suggest future headways that would finally allow the scientific understanding of the relationship between gut microbiome and FA. This review summarizes the current knowledge in the field of FA and insights into the future advances that will be achieved by applying proteomic techniques to study the GI tract microbiome in the field of FA and their medical treatment. Metaproteomics, a proteomics experimental approach of great interest in the study of GI tract microbiota, aims to analyze and identify all the proteins in complex environmental microbial communities; with shotgun proteomics, which uses liquid chromatography (LC) for separation and tandem mass spectrometry (MS/MS) for analysis, as it is the most promising technique in this field. MDPI 2023-01-23 /pmc/articles/PMC9917015/ /pubmed/36768555 http://dx.doi.org/10.3390/ijms24032234 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Abril, Ana G. Carrera, Mónica Sánchez-Pérez, Ángeles Villa, Tomás G. Gut Microbiome Proteomics in Food Allergies |
title | Gut Microbiome Proteomics in Food Allergies |
title_full | Gut Microbiome Proteomics in Food Allergies |
title_fullStr | Gut Microbiome Proteomics in Food Allergies |
title_full_unstemmed | Gut Microbiome Proteomics in Food Allergies |
title_short | Gut Microbiome Proteomics in Food Allergies |
title_sort | gut microbiome proteomics in food allergies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917015/ https://www.ncbi.nlm.nih.gov/pubmed/36768555 http://dx.doi.org/10.3390/ijms24032234 |
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