Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order...

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Detalles Bibliográficos
Autores principales: Lee, Haena, Jeon, Yejin, Moon, Hyejin, Lee, Eunjoo H., Lee, Tae Hoon, Kim, Hakwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917024/
https://www.ncbi.nlm.nih.gov/pubmed/36769036
http://dx.doi.org/10.3390/ijms24032713
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author Lee, Haena
Jeon, Yejin
Moon, Hyejin
Lee, Eunjoo H.
Lee, Tae Hoon
Kim, Hakwon
author_facet Lee, Haena
Jeon, Yejin
Moon, Hyejin
Lee, Eunjoo H.
Lee, Tae Hoon
Kim, Hakwon
author_sort Lee, Haena
collection PubMed
description In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.
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spelling pubmed-99170242023-02-11 Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines Lee, Haena Jeon, Yejin Moon, Hyejin Lee, Eunjoo H. Lee, Tae Hoon Kim, Hakwon Int J Mol Sci Communication In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes. MDPI 2023-02-01 /pmc/articles/PMC9917024/ /pubmed/36769036 http://dx.doi.org/10.3390/ijms24032713 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lee, Haena
Jeon, Yejin
Moon, Hyejin
Lee, Eunjoo H.
Lee, Tae Hoon
Kim, Hakwon
Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title_full Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title_fullStr Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title_full_unstemmed Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title_short Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines
title_sort synthesis of 1,4-dialkoxynaphthalene-based imidazolium salts and their cytotoxicity in cancer cell lines
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917024/
https://www.ncbi.nlm.nih.gov/pubmed/36769036
http://dx.doi.org/10.3390/ijms24032713
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