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SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents
Parahydrogen (p-H(2))-based techniques are known to drastically enhance NMR signals but are usually limited by p-H(2) supply. This work reports p-H(2)-based SABRE hyperpolarization at p-H(2) pressures of hundreds of bar, far beyond the typical ten bar currently reported in the literature. A recently...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917027/ https://www.ncbi.nlm.nih.gov/pubmed/36768786 http://dx.doi.org/10.3390/ijms24032465 |
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author | Duchowny, Anton Denninger, Johannes Lohmann, Lars Theis, Thomas Lehmkuhl, Sören Adams, Alina |
author_facet | Duchowny, Anton Denninger, Johannes Lohmann, Lars Theis, Thomas Lehmkuhl, Sören Adams, Alina |
author_sort | Duchowny, Anton |
collection | PubMed |
description | Parahydrogen (p-H(2))-based techniques are known to drastically enhance NMR signals but are usually limited by p-H(2) supply. This work reports p-H(2)-based SABRE hyperpolarization at p-H(2) pressures of hundreds of bar, far beyond the typical ten bar currently reported in the literature. A recently designed high-pressure setup was utilized to compress p-H(2) gas up to 200 bar. The measurements were conducted using a sapphire high-pressure NMR tube and a 43 MHz benchtop NMR spectrometer. In standard methanol solutions, it could be shown that the signal intensities increased with pressure until they eventually reached a plateau. A polarization of about 2%, equal to a molar polarization of 1.2 mmol L(−1), could be achieved for the sample with the highest substrate concentration. While the signal plateaued, the H(2) solubility increased linearly with pressure from 1 to 200 bar, indicating that p-H(2) availability is not the limiting factor in signal enhancement beyond a certain pressure, depending on sample composition. Furthermore, the possibility of using liquefied ethane and compressed CO(2) as removable solvents for hyperpolarization was demonstrated. The use of high pressures together with quickly removable organic/non-organic solvents represents an important breakthrough in the field of hyperpolarization, advancing SABRE as a promising tool for materials science, biophysics, and molecular imaging. |
format | Online Article Text |
id | pubmed-9917027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99170272023-02-11 SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents Duchowny, Anton Denninger, Johannes Lohmann, Lars Theis, Thomas Lehmkuhl, Sören Adams, Alina Int J Mol Sci Communication Parahydrogen (p-H(2))-based techniques are known to drastically enhance NMR signals but are usually limited by p-H(2) supply. This work reports p-H(2)-based SABRE hyperpolarization at p-H(2) pressures of hundreds of bar, far beyond the typical ten bar currently reported in the literature. A recently designed high-pressure setup was utilized to compress p-H(2) gas up to 200 bar. The measurements were conducted using a sapphire high-pressure NMR tube and a 43 MHz benchtop NMR spectrometer. In standard methanol solutions, it could be shown that the signal intensities increased with pressure until they eventually reached a plateau. A polarization of about 2%, equal to a molar polarization of 1.2 mmol L(−1), could be achieved for the sample with the highest substrate concentration. While the signal plateaued, the H(2) solubility increased linearly with pressure from 1 to 200 bar, indicating that p-H(2) availability is not the limiting factor in signal enhancement beyond a certain pressure, depending on sample composition. Furthermore, the possibility of using liquefied ethane and compressed CO(2) as removable solvents for hyperpolarization was demonstrated. The use of high pressures together with quickly removable organic/non-organic solvents represents an important breakthrough in the field of hyperpolarization, advancing SABRE as a promising tool for materials science, biophysics, and molecular imaging. MDPI 2023-01-27 /pmc/articles/PMC9917027/ /pubmed/36768786 http://dx.doi.org/10.3390/ijms24032465 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Duchowny, Anton Denninger, Johannes Lohmann, Lars Theis, Thomas Lehmkuhl, Sören Adams, Alina SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title | SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title_full | SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title_fullStr | SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title_full_unstemmed | SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title_short | SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents |
title_sort | sabre hyperpolarization with up to 200 bar parahydrogen in standard and quickly removable solvents |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917027/ https://www.ncbi.nlm.nih.gov/pubmed/36768786 http://dx.doi.org/10.3390/ijms24032465 |
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