Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role and source in multiple myeloma (MM) are unclear. Here, we evaluated TIMP1 protein and mRNA levels in bone marrow (BM...

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Detalles Bibliográficos
Autores principales: Ishihara, Rei, Oda, Tsukasa, Murakami, Yuki, Matsumura, Ikuko, Watanabe, Saki, Asao, Yuta, Masuda, Yuta, Gotoh, Nanami, Kasamatsu, Tetsuhiro, Takei, Hisashi, Kobayashi, Nobuhiko, Sasaki, Nobuo, Saitoh, Takayuki, Murakami, Hirokazu, Handa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917104/
https://www.ncbi.nlm.nih.gov/pubmed/36768545
http://dx.doi.org/10.3390/ijms24032216

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