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Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy

We evaluated biomarkers related to kidney fibrosis for the outcome of patients with IgA nephropathy (IgAN). Clinical parameters (estimated glomerular filtration rate, hypertension, proteinuria) and histological findings were assessed in 134 patients with IgAN at the time of diagnosis and followed up...

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Autores principales: Neprasova, Michaela, Maixnerova, Dita, Sparding, Nadja, Genovese, Federica, Karsdal, Morten Asser, Koprivova, Helena, Kollar, Marek, Suchanek, Miloslav, Hruskova, Zdenka, Tesar, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917115/
https://www.ncbi.nlm.nih.gov/pubmed/36768385
http://dx.doi.org/10.3390/ijms24032064
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author Neprasova, Michaela
Maixnerova, Dita
Sparding, Nadja
Genovese, Federica
Karsdal, Morten Asser
Koprivova, Helena
Kollar, Marek
Suchanek, Miloslav
Hruskova, Zdenka
Tesar, Vladimir
author_facet Neprasova, Michaela
Maixnerova, Dita
Sparding, Nadja
Genovese, Federica
Karsdal, Morten Asser
Koprivova, Helena
Kollar, Marek
Suchanek, Miloslav
Hruskova, Zdenka
Tesar, Vladimir
author_sort Neprasova, Michaela
collection PubMed
description We evaluated biomarkers related to kidney fibrosis for the outcome of patients with IgA nephropathy (IgAN). Clinical parameters (estimated glomerular filtration rate, hypertension, proteinuria) and histological findings were assessed in 134 patients with IgAN at the time of diagnosis and followed up prospectively (mean follow-up time, 56.5 months). We measured biomarkers of collagen and laminin turnover in serum and urine collected at the time of kidney biopsy using a novel enzyme-linked immunosorbent assay. Linear discriminant analysis and logistic regression models were used to predict the patient’s kidney outcome. Five serum and urine biomarkers of laminin and collagen turnover (sLG1M, sPRO-C3, sPRO-C6, uPRO-C6/Cr, uC3M/Cr) could significantly differentiae IgAN patients with a worse prognosis. Clinical parameters (glomerular filtration rate (GFR), proteinuria) distinguished patients at risk of IgAN progression with a specificity of 87.3% and a sensitivity of 45.2% (area under the curve-AUC 0.751). The addition of the biomarkers significantly increased the prognostic ability with a specificity of 85.1% and a sensitivity of 73.3% (AUC 0.905). We have identified three serum (sLG1M, sPRO-C3, sPRO-C6) and two urinary markers (uPRO-C6/Cr, u-C3M /Cr) that significantly improve the prognostic ability of markers of kidney function to identify an IgAN patient’s risk of progressing to ESKD.
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spelling pubmed-99171152023-02-11 Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy Neprasova, Michaela Maixnerova, Dita Sparding, Nadja Genovese, Federica Karsdal, Morten Asser Koprivova, Helena Kollar, Marek Suchanek, Miloslav Hruskova, Zdenka Tesar, Vladimir Int J Mol Sci Article We evaluated biomarkers related to kidney fibrosis for the outcome of patients with IgA nephropathy (IgAN). Clinical parameters (estimated glomerular filtration rate, hypertension, proteinuria) and histological findings were assessed in 134 patients with IgAN at the time of diagnosis and followed up prospectively (mean follow-up time, 56.5 months). We measured biomarkers of collagen and laminin turnover in serum and urine collected at the time of kidney biopsy using a novel enzyme-linked immunosorbent assay. Linear discriminant analysis and logistic regression models were used to predict the patient’s kidney outcome. Five serum and urine biomarkers of laminin and collagen turnover (sLG1M, sPRO-C3, sPRO-C6, uPRO-C6/Cr, uC3M/Cr) could significantly differentiae IgAN patients with a worse prognosis. Clinical parameters (glomerular filtration rate (GFR), proteinuria) distinguished patients at risk of IgAN progression with a specificity of 87.3% and a sensitivity of 45.2% (area under the curve-AUC 0.751). The addition of the biomarkers significantly increased the prognostic ability with a specificity of 85.1% and a sensitivity of 73.3% (AUC 0.905). We have identified three serum (sLG1M, sPRO-C3, sPRO-C6) and two urinary markers (uPRO-C6/Cr, u-C3M /Cr) that significantly improve the prognostic ability of markers of kidney function to identify an IgAN patient’s risk of progressing to ESKD. MDPI 2023-01-20 /pmc/articles/PMC9917115/ /pubmed/36768385 http://dx.doi.org/10.3390/ijms24032064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neprasova, Michaela
Maixnerova, Dita
Sparding, Nadja
Genovese, Federica
Karsdal, Morten Asser
Koprivova, Helena
Kollar, Marek
Suchanek, Miloslav
Hruskova, Zdenka
Tesar, Vladimir
Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title_full Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title_fullStr Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title_full_unstemmed Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title_short Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy
title_sort serum and urine biomarkers related to kidney fibrosis predict kidney outcome in czech patients with iga nephropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917115/
https://www.ncbi.nlm.nih.gov/pubmed/36768385
http://dx.doi.org/10.3390/ijms24032064
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