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Nanomaterials and Their Impact on the Immune System

Nanomaterials have been the focus of intensive development and research in the medical and industrial sectors over the past several decades. Some studies have found that these compounds can have a detrimental impact on living organisms, including their cellular components. Despite the obvious advant...

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Autores principales: Aljabali, Alaa A., Obeid, Mohammad A., Bashatwah, Rasha M., Serrano-Aroca, Ángel, Mishra, Vijay, Mishra, Yachana, El-Tanani, Mohamed, Hromić-Jahjefendić, Altijana, Kapoor, Deepak N., Goyal, Rohit, Naikoo, Gowhar A., Tambuwala, Murtaza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917130/
https://www.ncbi.nlm.nih.gov/pubmed/36768330
http://dx.doi.org/10.3390/ijms24032008
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author Aljabali, Alaa A.
Obeid, Mohammad A.
Bashatwah, Rasha M.
Serrano-Aroca, Ángel
Mishra, Vijay
Mishra, Yachana
El-Tanani, Mohamed
Hromić-Jahjefendić, Altijana
Kapoor, Deepak N.
Goyal, Rohit
Naikoo, Gowhar A.
Tambuwala, Murtaza M.
author_facet Aljabali, Alaa A.
Obeid, Mohammad A.
Bashatwah, Rasha M.
Serrano-Aroca, Ángel
Mishra, Vijay
Mishra, Yachana
El-Tanani, Mohamed
Hromić-Jahjefendić, Altijana
Kapoor, Deepak N.
Goyal, Rohit
Naikoo, Gowhar A.
Tambuwala, Murtaza M.
author_sort Aljabali, Alaa A.
collection PubMed
description Nanomaterials have been the focus of intensive development and research in the medical and industrial sectors over the past several decades. Some studies have found that these compounds can have a detrimental impact on living organisms, including their cellular components. Despite the obvious advantages of using nanomaterials in a wide range of applications, there is sometimes skepticism caused by the lack of substantial proof that evaluates potential toxicities. The interactions of nanoparticles (NPs) with cells of the immune system and their biomolecule pathways are an area of interest for researchers. It is possible to modify NPs so that they are not recognized by the immune system or so that they suppress or stimulate the immune system in a targeted manner. In this review, we look at the literature on nanomaterials for immunostimulation and immunosuppression and their impact on how changing the physicochemical features of the particles could alter their interactions with immune cells for the better or for the worse (immunotoxicity). We also look into whether the NPs have a unique or unexpected (but desired) effect on the immune system, and whether the surface grafting of polymers or surface coatings makes stealth nanomaterials that the immune system cannot find and get rid of.
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spelling pubmed-99171302023-02-11 Nanomaterials and Their Impact on the Immune System Aljabali, Alaa A. Obeid, Mohammad A. Bashatwah, Rasha M. Serrano-Aroca, Ángel Mishra, Vijay Mishra, Yachana El-Tanani, Mohamed Hromić-Jahjefendić, Altijana Kapoor, Deepak N. Goyal, Rohit Naikoo, Gowhar A. Tambuwala, Murtaza M. Int J Mol Sci Review Nanomaterials have been the focus of intensive development and research in the medical and industrial sectors over the past several decades. Some studies have found that these compounds can have a detrimental impact on living organisms, including their cellular components. Despite the obvious advantages of using nanomaterials in a wide range of applications, there is sometimes skepticism caused by the lack of substantial proof that evaluates potential toxicities. The interactions of nanoparticles (NPs) with cells of the immune system and their biomolecule pathways are an area of interest for researchers. It is possible to modify NPs so that they are not recognized by the immune system or so that they suppress or stimulate the immune system in a targeted manner. In this review, we look at the literature on nanomaterials for immunostimulation and immunosuppression and their impact on how changing the physicochemical features of the particles could alter their interactions with immune cells for the better or for the worse (immunotoxicity). We also look into whether the NPs have a unique or unexpected (but desired) effect on the immune system, and whether the surface grafting of polymers or surface coatings makes stealth nanomaterials that the immune system cannot find and get rid of. MDPI 2023-01-19 /pmc/articles/PMC9917130/ /pubmed/36768330 http://dx.doi.org/10.3390/ijms24032008 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aljabali, Alaa A.
Obeid, Mohammad A.
Bashatwah, Rasha M.
Serrano-Aroca, Ángel
Mishra, Vijay
Mishra, Yachana
El-Tanani, Mohamed
Hromić-Jahjefendić, Altijana
Kapoor, Deepak N.
Goyal, Rohit
Naikoo, Gowhar A.
Tambuwala, Murtaza M.
Nanomaterials and Their Impact on the Immune System
title Nanomaterials and Their Impact on the Immune System
title_full Nanomaterials and Their Impact on the Immune System
title_fullStr Nanomaterials and Their Impact on the Immune System
title_full_unstemmed Nanomaterials and Their Impact on the Immune System
title_short Nanomaterials and Their Impact on the Immune System
title_sort nanomaterials and their impact on the immune system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917130/
https://www.ncbi.nlm.nih.gov/pubmed/36768330
http://dx.doi.org/10.3390/ijms24032008
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