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Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies

Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics approach, we investigated the occurrence...

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Detalles Bibliográficos
Autores principales:	Scalia, Federica, Lo Bosco, Giosuè, Paladino, Letizia, Vitale, Alessandra Maria, Noori, Leila, Conway de Macario, Everly, Macario, Alberto J. L., Bucchieri, Fabio, Cappello, Francesco, Lo Celso, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917133/ https://www.ncbi.nlm.nih.gov/pubmed/36768350 http://dx.doi.org/10.3390/ijms24032018

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