Cargando…
Microglial Cannabinoid CB(2) Receptors in Pain Modulation
Pain, especially chronic pain, can strongly affect patients’ quality of life. Cannabinoids ponhave been reported to produce potent analgesic effects in different preclinical pain models, where they primarily function as agonists of G(i/o) protein-coupled cannabinoid CB(1) and CB(2) receptors. The CB...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917135/ https://www.ncbi.nlm.nih.gov/pubmed/36768668 http://dx.doi.org/10.3390/ijms24032348 |
_version_ | 1784886297157959680 |
---|---|
author | Xu, Kangtai Wu, Yifei Tian, Zhuangzhuang Xu, Yuanfan Wu, Chaoran Wang, Zilong |
author_facet | Xu, Kangtai Wu, Yifei Tian, Zhuangzhuang Xu, Yuanfan Wu, Chaoran Wang, Zilong |
author_sort | Xu, Kangtai |
collection | PubMed |
description | Pain, especially chronic pain, can strongly affect patients’ quality of life. Cannabinoids ponhave been reported to produce potent analgesic effects in different preclinical pain models, where they primarily function as agonists of G(i/o) protein-coupled cannabinoid CB(1) and CB(2) receptors. The CB(1) receptors are abundantly expressed in both the peripheral and central nervous systems. The central activation of CB(1) receptors is strongly associated with psychotropic adverse effects, thus largely limiting its therapeutic potential. However, the CB(2) receptors are promising targets for pain treatment without psychotropic adverse effects, as they are primarily expressed in immune cells. Additionally, as the resident immune cells in the central nervous system, microglia are increasingly recognized as critical players in chronic pain. Accumulating evidence has demonstrated that the expression of CB(2) receptors is significantly increased in activated microglia in the spinal cord, which exerts protective consequences within the surrounding neural circuitry by regulating the activity and function of microglia. In this review, we focused on recent advances in understanding the role of microglial CB(2) receptors in spinal nociceptive circuitry, highlighting the mechanism of CB(2) receptors in modulating microglia function and its implications for CB(2) receptor- selective agonist-mediated analgesia. |
format | Online Article Text |
id | pubmed-9917135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99171352023-02-11 Microglial Cannabinoid CB(2) Receptors in Pain Modulation Xu, Kangtai Wu, Yifei Tian, Zhuangzhuang Xu, Yuanfan Wu, Chaoran Wang, Zilong Int J Mol Sci Review Pain, especially chronic pain, can strongly affect patients’ quality of life. Cannabinoids ponhave been reported to produce potent analgesic effects in different preclinical pain models, where they primarily function as agonists of G(i/o) protein-coupled cannabinoid CB(1) and CB(2) receptors. The CB(1) receptors are abundantly expressed in both the peripheral and central nervous systems. The central activation of CB(1) receptors is strongly associated with psychotropic adverse effects, thus largely limiting its therapeutic potential. However, the CB(2) receptors are promising targets for pain treatment without psychotropic adverse effects, as they are primarily expressed in immune cells. Additionally, as the resident immune cells in the central nervous system, microglia are increasingly recognized as critical players in chronic pain. Accumulating evidence has demonstrated that the expression of CB(2) receptors is significantly increased in activated microglia in the spinal cord, which exerts protective consequences within the surrounding neural circuitry by regulating the activity and function of microglia. In this review, we focused on recent advances in understanding the role of microglial CB(2) receptors in spinal nociceptive circuitry, highlighting the mechanism of CB(2) receptors in modulating microglia function and its implications for CB(2) receptor- selective agonist-mediated analgesia. MDPI 2023-01-25 /pmc/articles/PMC9917135/ /pubmed/36768668 http://dx.doi.org/10.3390/ijms24032348 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xu, Kangtai Wu, Yifei Tian, Zhuangzhuang Xu, Yuanfan Wu, Chaoran Wang, Zilong Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title | Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title_full | Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title_fullStr | Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title_full_unstemmed | Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title_short | Microglial Cannabinoid CB(2) Receptors in Pain Modulation |
title_sort | microglial cannabinoid cb(2) receptors in pain modulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917135/ https://www.ncbi.nlm.nih.gov/pubmed/36768668 http://dx.doi.org/10.3390/ijms24032348 |
work_keys_str_mv | AT xukangtai microglialcannabinoidcb2receptorsinpainmodulation AT wuyifei microglialcannabinoidcb2receptorsinpainmodulation AT tianzhuangzhuang microglialcannabinoidcb2receptorsinpainmodulation AT xuyuanfan microglialcannabinoidcb2receptorsinpainmodulation AT wuchaoran microglialcannabinoidcb2receptorsinpainmodulation AT wangzilong microglialcannabinoidcb2receptorsinpainmodulation |