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A Comprehensive Review of mRNA Vaccines
mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917162/ https://www.ncbi.nlm.nih.gov/pubmed/36769023 http://dx.doi.org/10.3390/ijms24032700 |
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author | Gote, Vrinda Bolla, Pradeep Kumar Kommineni, Nagavendra Butreddy, Arun Nukala, Pavan Kumar Palakurthi, Sushesh Srivatsa Khan, Wahid |
author_facet | Gote, Vrinda Bolla, Pradeep Kumar Kommineni, Nagavendra Butreddy, Arun Nukala, Pavan Kumar Palakurthi, Sushesh Srivatsa Khan, Wahid |
author_sort | Gote, Vrinda |
collection | PubMed |
description | mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized. |
format | Online Article Text |
id | pubmed-9917162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99171622023-02-11 A Comprehensive Review of mRNA Vaccines Gote, Vrinda Bolla, Pradeep Kumar Kommineni, Nagavendra Butreddy, Arun Nukala, Pavan Kumar Palakurthi, Sushesh Srivatsa Khan, Wahid Int J Mol Sci Review mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized. MDPI 2023-01-31 /pmc/articles/PMC9917162/ /pubmed/36769023 http://dx.doi.org/10.3390/ijms24032700 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gote, Vrinda Bolla, Pradeep Kumar Kommineni, Nagavendra Butreddy, Arun Nukala, Pavan Kumar Palakurthi, Sushesh Srivatsa Khan, Wahid A Comprehensive Review of mRNA Vaccines |
title | A Comprehensive Review of mRNA Vaccines |
title_full | A Comprehensive Review of mRNA Vaccines |
title_fullStr | A Comprehensive Review of mRNA Vaccines |
title_full_unstemmed | A Comprehensive Review of mRNA Vaccines |
title_short | A Comprehensive Review of mRNA Vaccines |
title_sort | comprehensive review of mrna vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917162/ https://www.ncbi.nlm.nih.gov/pubmed/36769023 http://dx.doi.org/10.3390/ijms24032700 |
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