Cargando…

A Comprehensive Review of mRNA Vaccines

mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity...

Descripción completa

Detalles Bibliográficos
Autores principales: Gote, Vrinda, Bolla, Pradeep Kumar, Kommineni, Nagavendra, Butreddy, Arun, Nukala, Pavan Kumar, Palakurthi, Sushesh Srivatsa, Khan, Wahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917162/
https://www.ncbi.nlm.nih.gov/pubmed/36769023
http://dx.doi.org/10.3390/ijms24032700
_version_ 1784886303843680256
author Gote, Vrinda
Bolla, Pradeep Kumar
Kommineni, Nagavendra
Butreddy, Arun
Nukala, Pavan Kumar
Palakurthi, Sushesh Srivatsa
Khan, Wahid
author_facet Gote, Vrinda
Bolla, Pradeep Kumar
Kommineni, Nagavendra
Butreddy, Arun
Nukala, Pavan Kumar
Palakurthi, Sushesh Srivatsa
Khan, Wahid
author_sort Gote, Vrinda
collection PubMed
description mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized.
format Online
Article
Text
id pubmed-9917162
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99171622023-02-11 A Comprehensive Review of mRNA Vaccines Gote, Vrinda Bolla, Pradeep Kumar Kommineni, Nagavendra Butreddy, Arun Nukala, Pavan Kumar Palakurthi, Sushesh Srivatsa Khan, Wahid Int J Mol Sci Review mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized. MDPI 2023-01-31 /pmc/articles/PMC9917162/ /pubmed/36769023 http://dx.doi.org/10.3390/ijms24032700 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gote, Vrinda
Bolla, Pradeep Kumar
Kommineni, Nagavendra
Butreddy, Arun
Nukala, Pavan Kumar
Palakurthi, Sushesh Srivatsa
Khan, Wahid
A Comprehensive Review of mRNA Vaccines
title A Comprehensive Review of mRNA Vaccines
title_full A Comprehensive Review of mRNA Vaccines
title_fullStr A Comprehensive Review of mRNA Vaccines
title_full_unstemmed A Comprehensive Review of mRNA Vaccines
title_short A Comprehensive Review of mRNA Vaccines
title_sort comprehensive review of mrna vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917162/
https://www.ncbi.nlm.nih.gov/pubmed/36769023
http://dx.doi.org/10.3390/ijms24032700
work_keys_str_mv AT gotevrinda acomprehensivereviewofmrnavaccines
AT bollapradeepkumar acomprehensivereviewofmrnavaccines
AT kommineninagavendra acomprehensivereviewofmrnavaccines
AT butreddyarun acomprehensivereviewofmrnavaccines
AT nukalapavankumar acomprehensivereviewofmrnavaccines
AT palakurthisusheshsrivatsa acomprehensivereviewofmrnavaccines
AT khanwahid acomprehensivereviewofmrnavaccines
AT gotevrinda comprehensivereviewofmrnavaccines
AT bollapradeepkumar comprehensivereviewofmrnavaccines
AT kommineninagavendra comprehensivereviewofmrnavaccines
AT butreddyarun comprehensivereviewofmrnavaccines
AT nukalapavankumar comprehensivereviewofmrnavaccines
AT palakurthisusheshsrivatsa comprehensivereviewofmrnavaccines
AT khanwahid comprehensivereviewofmrnavaccines