Cargando…

Hyperpolarized (13)C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts

There is currently no consensus to determine which advanced melanoma patients will benefit from immunotherapy, highlighting the critical need to identify early-response biomarkers to immune checkpoint inhibitors. The aim of this work was to evaluate in vivo metabolic spectroscopy using hyperpolarize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farah, Chantale, Neveu, Marie-Aline, Bouzin, Caroline, Knezevic, Zorica, Gallez, Bernard, Leucci, Eleonora, Baurain, Jean-François, Mignion, Lionel, Jordan, Bénédicte F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917169/ https://www.ncbi.nlm.nih.gov/pubmed/36768822 http://dx.doi.org/10.3390/ijms24032499

Ejemplares similares

Combined HP (13)C Pyruvate and (13)C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts
por: Farah, Chantale, et al.
Publicado: (2022)

Metabolic imaging using hyperpolarized (13)C‐pyruvate to assess sensitivity to the B‐Raf inhibitor vemurafenib in melanoma cells and xenografts
por: Acciardo, Stefania, et al.
Publicado: (2019)

Imaging markers of response to combined BRAF and MEK inhibition in BRAF mutated vemurafenib-sensitive and resistant melanomas
por: Acciardo, Stefania, et al.
Publicado: (2018)

Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI
por: Buyse, Chloé, et al.
Publicado: (2021)

Probing Early Tumor Response to Radiation Therapy Using Hyperpolarized [1-(13)C]pyruvate in MDA-MB-231 Xenografts
por: Chen, Albert P., et al.
Publicado: (2013)

Correction: Probing Early Tumor Response to Radiation Therapy Using Hyperpolarized [1-(13)C]pyruvate in MDA-MB-231 Xenografts
por: Chen, Albert P., et al.
Publicado: (2013)

Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization?
por: d’Hose, Donatienne, et al.
Publicado: (2022)

Synthesis of (13)C and (2)H Labeled Vinyl Pyruvate and Hyperpolarization of Pyruvate
por: Brahms, Arne, et al.
Publicado: (2022)

Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐(13)C]pyruvate MRS and [(18)F]FDG‐PET
por: van Heijster, Frits H.A., et al.
Publicado: (2020)

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate
por: Serrao, Eva M., et al.
Publicado: (2016)

Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies
por: Larson, Peder EZ, et al.
Publicado: (2023)

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
por: Marco-Rius, Irene, et al.
Publicado: (2013)

The Blood Flow Shutdown Induced by Combretastatin A4 Impairs Gemcitabine Delivery in a Mouse Hepatocarcinoma
por: Fruytier, Anne-Catherine, et al.
Publicado: (2016)

A Catalyzing Phantom for Reproducible Dynamic Conversion of Hyperpolarized [1-(13)C]-Pyruvate
por: Walker, Christopher M., et al.
Publicado: (2013)

Metabolism of hyperpolarized [1‐(13)C]pyruvate through alternate pathways in rat liver
por: Jin, Eunsook S., et al.
Publicado: (2016)

Effects of fasting on serial measurements of hyperpolarized [1‐(13)C]pyruvate metabolism in tumors
por: Serrao, Eva M., et al.
Publicado: (2016)

Hyperpolarized [1‐(13)C] pyruvate as a possible diagnostic tool in liver disease
por: Kjærgaard, Uffe, et al.
Publicado: (2018)

EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells
por: d’Hose, Donatienne, et al.
Publicado: (2022)

Detection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate
por: Frijia, Francesca, et al.
Publicado: (2011)

Metabolite-Specific Echo-Planar Imaging of Hyperpolarized [1-(13)C]Pyruvate at 4.7 T
por: Blazey, Tyler, et al.
Publicado: (2021)

Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-(13)C]pyruvate MRI
por: Bøgh, Nikolaj, et al.
Publicado: (2022)

LIGHT-SABRE Hyperpolarizes 1-(13)C-Pyruvate Continuously without Magnetic Field Cycling
por: Pravdivtsev, Andrey N., et al.
Publicado: (2023)

Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target?
por: Gourgue, Florian, et al.
Publicado: (2020)

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer
por: Yelek, Caner, et al.
Publicado: (2022)

Radical‐free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV‐induced nonpersistent radicals
por: Zanella, Claudia C., et al.
Publicado: (2021)

2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography, diffusion-weighted magnetic resonance imaging, and choline spectroscopy to predict the activity of cetuximab in tumor xenografts derived from patients with squamous cell carcinoma of the head and neck
por: Mignion, Lionel, et al.
Publicado: (2018)

3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs
por: Menichetti, Luca, et al.
Publicado: (2013)

Modeling non‐linear kinetics of hyperpolarized [1‐(13)C] pyruvate in the crystalloid‐perfused rat heart
por: Mariotti, E., et al.
Publicado: (2016)

Assessment of Metformin induced changes in cardiac redox state using hyperpolarized[1-(13)C]pyruvate
por: Lewis, Andrew, et al.
Publicado: (2016)

Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-(13)C]pyruvate
por: Harris, Talia, et al.
Publicado: (2018)

Evaluation of Active Brown Adipose Tissue by the Use of Hyperpolarized [1-(13)C]Pyruvate MRI in Mice
por: Riis-Vestergaard, Mette Ji, et al.
Publicado: (2018)

Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-(13)C]pyruvate
por: DeVience, Stephen J., et al.
Publicado: (2017)

Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1‐13C]pyruvate
por: Lau, Angus Z., et al.
Publicado: (2016)

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-(13)C]Pyruvate as Markers of Renal Gluconeogenesis
por: Yoshihara, Hikari A. I., et al.
Publicado: (2021)

Initial Experience on Hyperpolarized [1-(13)C]Pyruvate MRI Multicenter Reproducibility—Are Multicenter Trials Feasible?
por: Bøgh, Nikolaj, et al.
Publicado: (2022)

Developing a Method to Estimate the Downstream Metabolite Signals from Hyperpolarized [1-(13)C]Pyruvate
por: Hsieh, Ching-Yi, et al.
Publicado: (2022)

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
por: Corbet, Cyril, et al.
Publicado: (2018)

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C‐pyruvate
por: Daniels, Charlie J., et al.
Publicado: (2016)

Molecular detection of inflammation in cell models using hyperpolarized (13)C-pyruvate
por: Sriram, Renuka, et al.
Publicado: (2018)

Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification
por: Buyse, Chloe, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qj28mcfu6rguscmg1n189tn6gt