PTCHD1 Binds Cholesterol but Not Sonic Hedgehog, Suggesting a Distinct Cellular Function

Deleterious mutations in the X-linked Patched domain-containing 1 (PTCHD1) gene may account for up to 1% of autism cases. Despite this, the PTCHD1 protein remains poorly understood. Structural similarities to Patched family proteins point to a role in sterol transport, but this hypothesis has not be...

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Detalles Bibliográficos
Autores principales: Hiltunen, Mimmu K., Timmis, Alex J., Thomsen, Maren, Gkotsi, Danai S., Iwaï, Hideo, Ribeiro, Orquidea M., Goldman, Adrian, Riobo-Del Galdo, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917202/
https://www.ncbi.nlm.nih.gov/pubmed/36769003
http://dx.doi.org/10.3390/ijms24032682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917202/
https://www.ncbi.nlm.nih.gov/pubmed/36769003
http://dx.doi.org/10.3390/ijms24032682

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