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Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review
The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917203/ https://www.ncbi.nlm.nih.gov/pubmed/36768686 http://dx.doi.org/10.3390/ijms24032358 |
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author | Lominadze, Zurabi Hill, Kareen Shaik, Mohammed Rifat Canakis, Justin P. Bourmaf, Mohammad Adams-Mardi, Cyrus Abutaleb, Ameer Mishra, Lopa Shetty, Kirti |
author_facet | Lominadze, Zurabi Hill, Kareen Shaik, Mohammed Rifat Canakis, Justin P. Bourmaf, Mohammad Adams-Mardi, Cyrus Abutaleb, Ameer Mishra, Lopa Shetty, Kirti |
author_sort | Lominadze, Zurabi |
collection | PubMed |
description | The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation. |
format | Online Article Text |
id | pubmed-9917203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99172032023-02-11 Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review Lominadze, Zurabi Hill, Kareen Shaik, Mohammed Rifat Canakis, Justin P. Bourmaf, Mohammad Adams-Mardi, Cyrus Abutaleb, Ameer Mishra, Lopa Shetty, Kirti Int J Mol Sci Review The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation. MDPI 2023-01-25 /pmc/articles/PMC9917203/ /pubmed/36768686 http://dx.doi.org/10.3390/ijms24032358 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lominadze, Zurabi Hill, Kareen Shaik, Mohammed Rifat Canakis, Justin P. Bourmaf, Mohammad Adams-Mardi, Cyrus Abutaleb, Ameer Mishra, Lopa Shetty, Kirti Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title | Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title_full | Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title_fullStr | Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title_full_unstemmed | Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title_short | Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review |
title_sort | immunotherapy for hepatocellular carcinoma in the setting of liver transplantation: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917203/ https://www.ncbi.nlm.nih.gov/pubmed/36768686 http://dx.doi.org/10.3390/ijms24032358 |
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