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Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons
Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesiu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917221/ https://www.ncbi.nlm.nih.gov/pubmed/36768774 http://dx.doi.org/10.3390/ijms24032452 |
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author | Bunge, Alexander Chiriac, Alexandru Sofronie, Mihaela Crăciunescu, Izabell Porav, Alin Sebastian Turcu, Rodica |
author_facet | Bunge, Alexander Chiriac, Alexandru Sofronie, Mihaela Crăciunescu, Izabell Porav, Alin Sebastian Turcu, Rodica |
author_sort | Bunge, Alexander |
collection | PubMed |
description | Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesium and pure iron, two metals commonly used in temporary stent research. In order to avoid blood clotting upon the introduction of the stent, they are often coated with anticoagulants. In this study, sulfated pectin, a heparin mimetic, was synthesized in different ways and used as coating on multiple iron–palladium alloys. The static and dynamic prothrombin time (PT) and activated partial thromboplastin time (APTT) of the prepared materials were compared to samples uncoated or coated with polyethylene glycol. While no large differences were observed in the prothrombin time measurements, the activated partial thromboplastin time increased significantly with all alloys coated with sulfated pectin. Aside from that, sulfated pectin synthesized by different methods also caused slight changes in the activated partial thromboplastin time. These findings show that iron–palladium alloys can be coated with anticoagulants to improve their utility as material for temporary stents. Sulfated pectin was characterized by nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy, and the coated alloys by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). |
format | Online Article Text |
id | pubmed-9917221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99172212023-02-11 Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons Bunge, Alexander Chiriac, Alexandru Sofronie, Mihaela Crăciunescu, Izabell Porav, Alin Sebastian Turcu, Rodica Int J Mol Sci Article Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesium and pure iron, two metals commonly used in temporary stent research. In order to avoid blood clotting upon the introduction of the stent, they are often coated with anticoagulants. In this study, sulfated pectin, a heparin mimetic, was synthesized in different ways and used as coating on multiple iron–palladium alloys. The static and dynamic prothrombin time (PT) and activated partial thromboplastin time (APTT) of the prepared materials were compared to samples uncoated or coated with polyethylene glycol. While no large differences were observed in the prothrombin time measurements, the activated partial thromboplastin time increased significantly with all alloys coated with sulfated pectin. Aside from that, sulfated pectin synthesized by different methods also caused slight changes in the activated partial thromboplastin time. These findings show that iron–palladium alloys can be coated with anticoagulants to improve their utility as material for temporary stents. Sulfated pectin was characterized by nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy, and the coated alloys by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). MDPI 2023-01-26 /pmc/articles/PMC9917221/ /pubmed/36768774 http://dx.doi.org/10.3390/ijms24032452 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bunge, Alexander Chiriac, Alexandru Sofronie, Mihaela Crăciunescu, Izabell Porav, Alin Sebastian Turcu, Rodica Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_full | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_fullStr | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_full_unstemmed | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_short | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_sort | anticoagulant properties of coated fe-pd ferromagnetic shape memory ribbons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917221/ https://www.ncbi.nlm.nih.gov/pubmed/36768774 http://dx.doi.org/10.3390/ijms24032452 |
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