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Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence
Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extrem...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917272/ https://www.ncbi.nlm.nih.gov/pubmed/36768804 http://dx.doi.org/10.3390/ijms24032483 |
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author | Cimmino, Giovanni Loffredo, Francesco S. De Rosa, Gennaro Cirillo, Plinio |
author_facet | Cimmino, Giovanni Loffredo, Francesco S. De Rosa, Gennaro Cirillo, Plinio |
author_sort | Cimmino, Giovanni |
collection | PubMed |
description | Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Mediterranean fever. To date, current guidelines of the European Society of Cardiology have included colchicine as first line choice for treatment of acute and recurrent pericarditis. Moreover, several studies have investigated its role in the clinical scenarios of cardiovascular disease including chronic and acute coronary syndromes with promising results. In this review, starting from a description of the mechanism(s) involved behind its anti-inflammatory effects, we give an overview on its potential effects in atherothrombosis and finally present an updated overview of clinical evidence on the role of this drug in cardiovascular disease. |
format | Online Article Text |
id | pubmed-9917272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99172722023-02-11 Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence Cimmino, Giovanni Loffredo, Francesco S. De Rosa, Gennaro Cirillo, Plinio Int J Mol Sci Review Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Mediterranean fever. To date, current guidelines of the European Society of Cardiology have included colchicine as first line choice for treatment of acute and recurrent pericarditis. Moreover, several studies have investigated its role in the clinical scenarios of cardiovascular disease including chronic and acute coronary syndromes with promising results. In this review, starting from a description of the mechanism(s) involved behind its anti-inflammatory effects, we give an overview on its potential effects in atherothrombosis and finally present an updated overview of clinical evidence on the role of this drug in cardiovascular disease. MDPI 2023-01-27 /pmc/articles/PMC9917272/ /pubmed/36768804 http://dx.doi.org/10.3390/ijms24032483 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cimmino, Giovanni Loffredo, Francesco S. De Rosa, Gennaro Cirillo, Plinio Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title | Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title_full | Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title_fullStr | Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title_full_unstemmed | Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title_short | Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence |
title_sort | colchicine in athero-thrombosis: molecular mechanisms and clinical evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917272/ https://www.ncbi.nlm.nih.gov/pubmed/36768804 http://dx.doi.org/10.3390/ijms24032483 |
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