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Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease

Background: Arterial stiffness influences the prognosis of patients with end-stage kidney disease; however, the factors that promote arterial stiffness in chronic kidney disease (CKD) patients remain unknown. We aimed to explore the clinical factors associated with arterial stiffness in CKD. Methods...

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Autores principales: Yao, Jin, Dong, Zheyi, Wang, Qian, Li, Zhe, Zhang, Weiguang, Lin, Wenwen, Luo, Yayong, Li, Hangtian, Guo, Xinru, Zhang, Li, Cai, Guangyan, Shen, Wanjun, Duan, Shuwei, Chen, Xiangmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917394/
https://www.ncbi.nlm.nih.gov/pubmed/36769724
http://dx.doi.org/10.3390/jcm12031077
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author Yao, Jin
Dong, Zheyi
Wang, Qian
Li, Zhe
Zhang, Weiguang
Lin, Wenwen
Luo, Yayong
Li, Hangtian
Guo, Xinru
Zhang, Li
Cai, Guangyan
Shen, Wanjun
Duan, Shuwei
Chen, Xiangmei
author_facet Yao, Jin
Dong, Zheyi
Wang, Qian
Li, Zhe
Zhang, Weiguang
Lin, Wenwen
Luo, Yayong
Li, Hangtian
Guo, Xinru
Zhang, Li
Cai, Guangyan
Shen, Wanjun
Duan, Shuwei
Chen, Xiangmei
author_sort Yao, Jin
collection PubMed
description Background: Arterial stiffness influences the prognosis of patients with end-stage kidney disease; however, the factors that promote arterial stiffness in chronic kidney disease (CKD) patients remain unknown. We aimed to explore the clinical factors associated with arterial stiffness in CKD. Methods: Between September 2017 and September 2022, all CKD patients treated at the Department of Nephrology, General Hospital of the Chinese People’s Liberation Army, excluding dialysis patients, were screened and their medical records within the last month were collected. Arterial stiffness was measured by the augmentation index (AIx). The correlative clinical factors with arterial stiffness were explored in different linear regression models. Results: 559 patients were included in the study. AIx@75 increased as the deterioration of CKDG1–CKDG5, with values of 1 (−9, 11), 5.5 (−4, 13.25), 9 (0, 16), 12 (1.5, 23.5), and 22 (13, 28), respectively (Z = 63.03, p < 0.001). Multivariate linear regression analysis showed that AIx@75 was positively associated with female sex (β = 8.926, 95% confidence interval (CI) 6.291, 11.562, p < 0.001), age (β = 0. 485, 95% CI 0.39, 0.58, p < 0.001), mean arterial pressure (MAP) (β = 0.255, 95% CI 0.159, 0.35, p < 0.001), and was negatively associated with ACEI/ARB (β = −4.466, 95% CI −6.963, −1.969, p < 0.001) and glucocorticoid (β = −3.163, 95% CI −6.143, −0.183, p = 0.038). Smoking, eGFR, hemoglobin, and cause of disease were associated with AIx@75 in multivariate linear regression models when considering factors partly. Conclusions: Female, age, smoking, MAP, eGFR, cause of disease, ACEI/ARB, and glucocorticoid were found to be associated with atherosclerosis in CKD patients.
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spelling pubmed-99173942023-02-11 Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease Yao, Jin Dong, Zheyi Wang, Qian Li, Zhe Zhang, Weiguang Lin, Wenwen Luo, Yayong Li, Hangtian Guo, Xinru Zhang, Li Cai, Guangyan Shen, Wanjun Duan, Shuwei Chen, Xiangmei J Clin Med Article Background: Arterial stiffness influences the prognosis of patients with end-stage kidney disease; however, the factors that promote arterial stiffness in chronic kidney disease (CKD) patients remain unknown. We aimed to explore the clinical factors associated with arterial stiffness in CKD. Methods: Between September 2017 and September 2022, all CKD patients treated at the Department of Nephrology, General Hospital of the Chinese People’s Liberation Army, excluding dialysis patients, were screened and their medical records within the last month were collected. Arterial stiffness was measured by the augmentation index (AIx). The correlative clinical factors with arterial stiffness were explored in different linear regression models. Results: 559 patients were included in the study. AIx@75 increased as the deterioration of CKDG1–CKDG5, with values of 1 (−9, 11), 5.5 (−4, 13.25), 9 (0, 16), 12 (1.5, 23.5), and 22 (13, 28), respectively (Z = 63.03, p < 0.001). Multivariate linear regression analysis showed that AIx@75 was positively associated with female sex (β = 8.926, 95% confidence interval (CI) 6.291, 11.562, p < 0.001), age (β = 0. 485, 95% CI 0.39, 0.58, p < 0.001), mean arterial pressure (MAP) (β = 0.255, 95% CI 0.159, 0.35, p < 0.001), and was negatively associated with ACEI/ARB (β = −4.466, 95% CI −6.963, −1.969, p < 0.001) and glucocorticoid (β = −3.163, 95% CI −6.143, −0.183, p = 0.038). Smoking, eGFR, hemoglobin, and cause of disease were associated with AIx@75 in multivariate linear regression models when considering factors partly. Conclusions: Female, age, smoking, MAP, eGFR, cause of disease, ACEI/ARB, and glucocorticoid were found to be associated with atherosclerosis in CKD patients. MDPI 2023-01-30 /pmc/articles/PMC9917394/ /pubmed/36769724 http://dx.doi.org/10.3390/jcm12031077 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yao, Jin
Dong, Zheyi
Wang, Qian
Li, Zhe
Zhang, Weiguang
Lin, Wenwen
Luo, Yayong
Li, Hangtian
Guo, Xinru
Zhang, Li
Cai, Guangyan
Shen, Wanjun
Duan, Shuwei
Chen, Xiangmei
Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title_full Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title_fullStr Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title_full_unstemmed Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title_short Clinical Factors Associated with Arterial Stiffness in Chronic Kidney Disease
title_sort clinical factors associated with arterial stiffness in chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917394/
https://www.ncbi.nlm.nih.gov/pubmed/36769724
http://dx.doi.org/10.3390/jcm12031077
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