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Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19

Background: Excess cardiovascular (CV) morbidity and mortality has been observed in patients with COVID-19. Both interleukin-32 (IL-32) and interleukin-34 (IL-34) have been hypothesized to contribute to CV involvement in COVID-19. Methods: This prospective, observational study of patients with labor...

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Autores principales: Kaufmann, Christoph C., Ahmed, Amro, Muthspiel, Marie, Rostocki, Isabella, Pogran, Edita, Zweiker, David, Burger, Achim Leo, Jäger, Bernhard, Aicher, Gabriele, Spiel, Alexander O., Vafai-Tabrizi, Florian, Gschwantler, Michael, Fasching, Peter, Wojta, Johann, Huber, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917403/
https://www.ncbi.nlm.nih.gov/pubmed/36769623
http://dx.doi.org/10.3390/jcm12030975
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author Kaufmann, Christoph C.
Ahmed, Amro
Muthspiel, Marie
Rostocki, Isabella
Pogran, Edita
Zweiker, David
Burger, Achim Leo
Jäger, Bernhard
Aicher, Gabriele
Spiel, Alexander O.
Vafai-Tabrizi, Florian
Gschwantler, Michael
Fasching, Peter
Wojta, Johann
Huber, Kurt
author_facet Kaufmann, Christoph C.
Ahmed, Amro
Muthspiel, Marie
Rostocki, Isabella
Pogran, Edita
Zweiker, David
Burger, Achim Leo
Jäger, Bernhard
Aicher, Gabriele
Spiel, Alexander O.
Vafai-Tabrizi, Florian
Gschwantler, Michael
Fasching, Peter
Wojta, Johann
Huber, Kurt
author_sort Kaufmann, Christoph C.
collection PubMed
description Background: Excess cardiovascular (CV) morbidity and mortality has been observed in patients with COVID-19. Both interleukin-32 (IL-32) and interleukin-34 (IL-34) have been hypothesized to contribute to CV involvement in COVID-19. Methods: This prospective, observational study of patients with laboratory-confirmed COVID-19 infection was conducted from 6 June to 22 December 2020 in a tertiary care hospital in Vienna, Austria. IL-32 and IL-34 levels on admission were collected and tested for their association with CV disease and short-term mortality in patients with COVID-19. CV disease was defined by the presence of coronary artery disease, heart failure, stroke or atrial fibrillation and patients were stratified by CV disease burden. Results: A total of 245 eligible patients with COVID-19 were included, of whom 37 (15.1%) reached the primary endpoint of 28-day mortality. Of the total sample, 161 had no CV disease (65.7%), 69 had one or two CV diseases (28.2%) and 15 patients had ≥three CV diseases (6.1%). Median levels of IL-32 and IL-34 at admission were comparable across the three groups of CV disease burden. IL-32 and IL-34 failed to predict mortality upon both univariable and multivariable Cox regression analysis. The two CV disease groups, however, had a significantly higher risk of mortality within 28 days (one or two CV diseases: crude HR 4.085 (95% CI, 1.913–8.725), p < 0.001 and ≥three CV diseases: crude HR 13.173 (95% CI, 5.425–31.985), p < 0.001). This association persisted for those with ≥three CV diseases after adjustment for age, gender and CV risk factors (adjusted HR 3.942 (95% CI, 1.288–12.068), p = 0.016). Conclusion: In our study population of hospitalized patients with COVID-19, IL-32 and IL-34 did not show any associations with CV disease or 28-day mortality in the context of COVID-19. Patients with multiple CV diseases, however, had a significantly increased risk of short-term mortality.
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spelling pubmed-99174032023-02-11 Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19 Kaufmann, Christoph C. Ahmed, Amro Muthspiel, Marie Rostocki, Isabella Pogran, Edita Zweiker, David Burger, Achim Leo Jäger, Bernhard Aicher, Gabriele Spiel, Alexander O. Vafai-Tabrizi, Florian Gschwantler, Michael Fasching, Peter Wojta, Johann Huber, Kurt J Clin Med Article Background: Excess cardiovascular (CV) morbidity and mortality has been observed in patients with COVID-19. Both interleukin-32 (IL-32) and interleukin-34 (IL-34) have been hypothesized to contribute to CV involvement in COVID-19. Methods: This prospective, observational study of patients with laboratory-confirmed COVID-19 infection was conducted from 6 June to 22 December 2020 in a tertiary care hospital in Vienna, Austria. IL-32 and IL-34 levels on admission were collected and tested for their association with CV disease and short-term mortality in patients with COVID-19. CV disease was defined by the presence of coronary artery disease, heart failure, stroke or atrial fibrillation and patients were stratified by CV disease burden. Results: A total of 245 eligible patients with COVID-19 were included, of whom 37 (15.1%) reached the primary endpoint of 28-day mortality. Of the total sample, 161 had no CV disease (65.7%), 69 had one or two CV diseases (28.2%) and 15 patients had ≥three CV diseases (6.1%). Median levels of IL-32 and IL-34 at admission were comparable across the three groups of CV disease burden. IL-32 and IL-34 failed to predict mortality upon both univariable and multivariable Cox regression analysis. The two CV disease groups, however, had a significantly higher risk of mortality within 28 days (one or two CV diseases: crude HR 4.085 (95% CI, 1.913–8.725), p < 0.001 and ≥three CV diseases: crude HR 13.173 (95% CI, 5.425–31.985), p < 0.001). This association persisted for those with ≥three CV diseases after adjustment for age, gender and CV risk factors (adjusted HR 3.942 (95% CI, 1.288–12.068), p = 0.016). Conclusion: In our study population of hospitalized patients with COVID-19, IL-32 and IL-34 did not show any associations with CV disease or 28-day mortality in the context of COVID-19. Patients with multiple CV diseases, however, had a significantly increased risk of short-term mortality. MDPI 2023-01-27 /pmc/articles/PMC9917403/ /pubmed/36769623 http://dx.doi.org/10.3390/jcm12030975 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaufmann, Christoph C.
Ahmed, Amro
Muthspiel, Marie
Rostocki, Isabella
Pogran, Edita
Zweiker, David
Burger, Achim Leo
Jäger, Bernhard
Aicher, Gabriele
Spiel, Alexander O.
Vafai-Tabrizi, Florian
Gschwantler, Michael
Fasching, Peter
Wojta, Johann
Huber, Kurt
Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title_full Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title_fullStr Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title_full_unstemmed Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title_short Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19
title_sort association of interleukin-32 and interleukin-34 with cardiovascular disease and short-term mortality in covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917403/
https://www.ncbi.nlm.nih.gov/pubmed/36769623
http://dx.doi.org/10.3390/jcm12030975
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