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Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil
Acute Localized Exanthematous Pustulosis (ALEP) is a rare skin reaction characterized by the sudden onset of multiple, small, sterile, non-follicular pustules in an erythematous and edematous base succeeding systemic drug administration. ALEP is considered a subtype of Acute Generalized Exanthematou...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917494/ https://www.ncbi.nlm.nih.gov/pubmed/36769479 http://dx.doi.org/10.3390/jcm12030831 |
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author | Makris, Michael Kanelleas, Antonios Papapostolou, Niki Pisimisi, Maria Katoulis, Alexander C. |
author_facet | Makris, Michael Kanelleas, Antonios Papapostolou, Niki Pisimisi, Maria Katoulis, Alexander C. |
author_sort | Makris, Michael |
collection | PubMed |
description | Acute Localized Exanthematous Pustulosis (ALEP) is a rare skin reaction characterized by the sudden onset of multiple, small, sterile, non-follicular pustules in an erythematous and edematous base succeeding systemic drug administration. ALEP is considered a subtype of Acute Generalized Exanthematous Pustulosis (AGEP), although the exact pathogenic mechanism of the disease remains poorly defined. Numerous drugs have been implicated in the pathogenesis of ALEP, while contact mechanisms have also been reported. Herein, we describe the first case of ALEP attributed to minoxidil in a female patient with androgenetic alopecia. The positivity of patch tests and the topical application of minoxidil proposes a contact-induced hypersensitivity reaction. Identifying new agents—including minoxidil—which serve as inducers of drug-specific T-cell-mediated responses in the clinical spectrum of ALEP, adds further value in understanding the complex, yet unknown, pathophysiological mechanisms of this rare drug hypersensitivity reaction. |
format | Online Article Text |
id | pubmed-9917494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99174942023-02-11 Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil Makris, Michael Kanelleas, Antonios Papapostolou, Niki Pisimisi, Maria Katoulis, Alexander C. J Clin Med Case Report Acute Localized Exanthematous Pustulosis (ALEP) is a rare skin reaction characterized by the sudden onset of multiple, small, sterile, non-follicular pustules in an erythematous and edematous base succeeding systemic drug administration. ALEP is considered a subtype of Acute Generalized Exanthematous Pustulosis (AGEP), although the exact pathogenic mechanism of the disease remains poorly defined. Numerous drugs have been implicated in the pathogenesis of ALEP, while contact mechanisms have also been reported. Herein, we describe the first case of ALEP attributed to minoxidil in a female patient with androgenetic alopecia. The positivity of patch tests and the topical application of minoxidil proposes a contact-induced hypersensitivity reaction. Identifying new agents—including minoxidil—which serve as inducers of drug-specific T-cell-mediated responses in the clinical spectrum of ALEP, adds further value in understanding the complex, yet unknown, pathophysiological mechanisms of this rare drug hypersensitivity reaction. MDPI 2023-01-20 /pmc/articles/PMC9917494/ /pubmed/36769479 http://dx.doi.org/10.3390/jcm12030831 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Makris, Michael Kanelleas, Antonios Papapostolou, Niki Pisimisi, Maria Katoulis, Alexander C. Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title | Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title_full | Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title_fullStr | Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title_full_unstemmed | Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title_short | Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil |
title_sort | acute localized exanthematous pustulosis (alep) caused by topical application of minoxidil |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917494/ https://www.ncbi.nlm.nih.gov/pubmed/36769479 http://dx.doi.org/10.3390/jcm12030831 |
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