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Natural Killer T-like Cells: Immunobiology and Role in Disease
CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917533/ https://www.ncbi.nlm.nih.gov/pubmed/36769064 http://dx.doi.org/10.3390/ijms24032743 |
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author | Almeida, Jani-Sofia Casanova, José Manuel Santos-Rosa, Manuel Tarazona, Raquel Solana, Rafael Rodrigues-Santos, Paulo |
author_facet | Almeida, Jani-Sofia Casanova, José Manuel Santos-Rosa, Manuel Tarazona, Raquel Solana, Rafael Rodrigues-Santos, Paulo |
author_sort | Almeida, Jani-Sofia |
collection | PubMed |
description | CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with “CD1d-independent” antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings. |
format | Online Article Text |
id | pubmed-9917533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99175332023-02-11 Natural Killer T-like Cells: Immunobiology and Role in Disease Almeida, Jani-Sofia Casanova, José Manuel Santos-Rosa, Manuel Tarazona, Raquel Solana, Rafael Rodrigues-Santos, Paulo Int J Mol Sci Review CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with “CD1d-independent” antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings. MDPI 2023-02-01 /pmc/articles/PMC9917533/ /pubmed/36769064 http://dx.doi.org/10.3390/ijms24032743 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Almeida, Jani-Sofia Casanova, José Manuel Santos-Rosa, Manuel Tarazona, Raquel Solana, Rafael Rodrigues-Santos, Paulo Natural Killer T-like Cells: Immunobiology and Role in Disease |
title | Natural Killer T-like Cells: Immunobiology and Role in Disease |
title_full | Natural Killer T-like Cells: Immunobiology and Role in Disease |
title_fullStr | Natural Killer T-like Cells: Immunobiology and Role in Disease |
title_full_unstemmed | Natural Killer T-like Cells: Immunobiology and Role in Disease |
title_short | Natural Killer T-like Cells: Immunobiology and Role in Disease |
title_sort | natural killer t-like cells: immunobiology and role in disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917533/ https://www.ncbi.nlm.nih.gov/pubmed/36769064 http://dx.doi.org/10.3390/ijms24032743 |
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