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Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)

Purpose: Accurate detection of cerebral microbleeds (CMBs) on susceptibility-weighted (SWI) magnetic resonance imaging (MRI) is crucial for the characterization of many neurological diseases. Low-field MRI offers greater access at lower costs and lower infrastructural requirements, but also reduced...

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Autores principales: Rusche, Thilo, Breit, Hanns-Christian, Bach, Michael, Wasserthal, Jakob, Gehweiler, Julian, Manneck, Sebastian, Lieb, Johanna M., De Marchis, Gian Marco, Psychogios, Marios, Sporns, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917536/
https://www.ncbi.nlm.nih.gov/pubmed/36769827
http://dx.doi.org/10.3390/jcm12031179
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author Rusche, Thilo
Breit, Hanns-Christian
Bach, Michael
Wasserthal, Jakob
Gehweiler, Julian
Manneck, Sebastian
Lieb, Johanna M.
De Marchis, Gian Marco
Psychogios, Marios
Sporns, Peter B.
author_facet Rusche, Thilo
Breit, Hanns-Christian
Bach, Michael
Wasserthal, Jakob
Gehweiler, Julian
Manneck, Sebastian
Lieb, Johanna M.
De Marchis, Gian Marco
Psychogios, Marios
Sporns, Peter B.
author_sort Rusche, Thilo
collection PubMed
description Purpose: Accurate detection of cerebral microbleeds (CMBs) on susceptibility-weighted (SWI) magnetic resonance imaging (MRI) is crucial for the characterization of many neurological diseases. Low-field MRI offers greater access at lower costs and lower infrastructural requirements, but also reduced susceptibility artifacts. We therefore evaluated the diagnostic performance for the detection of CMBs of a whole-body low-field MRI in a prospective cohort of suspected stroke patients compared to an established 1.5 T MRI. Methods: A prospective scanner comparison was performed including 27 patients, of whom 3 patients were excluded because the time interval was >1 h between acquisition of the 1.5 T and 0.55 T MRI. All SWI sequences were assessed for the presence, number, and localization of CMBs by two neuroradiologists and additionally underwent a Likert rating with respect to image impression, resolution, noise, contrast, and diagnostic quality. Results: A total of 24 patients with a mean age of 74 years were included (11 female). Both readers detected the same number and localization of microbleeds in all 24 datasets (sensitivity and specificity 100%; interreader reliability ϰ = 1), with CMBs only being observed in 12 patients. Likert ratings of the sequences at both field strengths regarding overall image quality and diagnostic quality did not reveal significant differences between the 0.55 T and 1.5 T sequences (p = 0.942; p = 0.672). For resolution and contrast, the 0.55 T sequences were even significantly superior (p < 0.0001; p < 0.0003), whereas the 1.5 T sequences were significantly superior (p < 0.0001) regarding noise. Conclusion: Low-field MRI at 0.55 T may have similar accuracy as 1.5 T scanners for the detection of microbleeds and thus may have great potential as a resource-efficient alternative in the near future.
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spelling pubmed-99175362023-02-11 Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI) Rusche, Thilo Breit, Hanns-Christian Bach, Michael Wasserthal, Jakob Gehweiler, Julian Manneck, Sebastian Lieb, Johanna M. De Marchis, Gian Marco Psychogios, Marios Sporns, Peter B. J Clin Med Article Purpose: Accurate detection of cerebral microbleeds (CMBs) on susceptibility-weighted (SWI) magnetic resonance imaging (MRI) is crucial for the characterization of many neurological diseases. Low-field MRI offers greater access at lower costs and lower infrastructural requirements, but also reduced susceptibility artifacts. We therefore evaluated the diagnostic performance for the detection of CMBs of a whole-body low-field MRI in a prospective cohort of suspected stroke patients compared to an established 1.5 T MRI. Methods: A prospective scanner comparison was performed including 27 patients, of whom 3 patients were excluded because the time interval was >1 h between acquisition of the 1.5 T and 0.55 T MRI. All SWI sequences were assessed for the presence, number, and localization of CMBs by two neuroradiologists and additionally underwent a Likert rating with respect to image impression, resolution, noise, contrast, and diagnostic quality. Results: A total of 24 patients with a mean age of 74 years were included (11 female). Both readers detected the same number and localization of microbleeds in all 24 datasets (sensitivity and specificity 100%; interreader reliability ϰ = 1), with CMBs only being observed in 12 patients. Likert ratings of the sequences at both field strengths regarding overall image quality and diagnostic quality did not reveal significant differences between the 0.55 T and 1.5 T sequences (p = 0.942; p = 0.672). For resolution and contrast, the 0.55 T sequences were even significantly superior (p < 0.0001; p < 0.0003), whereas the 1.5 T sequences were significantly superior (p < 0.0001) regarding noise. Conclusion: Low-field MRI at 0.55 T may have similar accuracy as 1.5 T scanners for the detection of microbleeds and thus may have great potential as a resource-efficient alternative in the near future. MDPI 2023-02-02 /pmc/articles/PMC9917536/ /pubmed/36769827 http://dx.doi.org/10.3390/jcm12031179 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rusche, Thilo
Breit, Hanns-Christian
Bach, Michael
Wasserthal, Jakob
Gehweiler, Julian
Manneck, Sebastian
Lieb, Johanna M.
De Marchis, Gian Marco
Psychogios, Marios
Sporns, Peter B.
Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title_full Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title_fullStr Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title_full_unstemmed Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title_short Prospective Assessment of Cerebral Microbleeds with Low-Field Magnetic Resonance Imaging (0.55 Tesla MRI)
title_sort prospective assessment of cerebral microbleeds with low-field magnetic resonance imaging (0.55 tesla mri)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917536/
https://www.ncbi.nlm.nih.gov/pubmed/36769827
http://dx.doi.org/10.3390/jcm12031179
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