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Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and one group of patients has developed a severe form of COVID-19 pneumonia with an urgent need for hospitalization and intensive care unit (ICU) admission. The aim of our study was to evaluate the prognostic r...

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Autores principales: Bajić, Dejana, Matijašević, Jovan, Andrijević, Ljiljana, Zarić, Bojan, Lalić-Popović, Mladena, Andrijević, Ilija, Todorović, Nemanja, Mihajlović, Andrea, Tapavički, Borislav, Ostojić, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917557/
https://www.ncbi.nlm.nih.gov/pubmed/36769843
http://dx.doi.org/10.3390/jcm12031197
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author Bajić, Dejana
Matijašević, Jovan
Andrijević, Ljiljana
Zarić, Bojan
Lalić-Popović, Mladena
Andrijević, Ilija
Todorović, Nemanja
Mihajlović, Andrea
Tapavički, Borislav
Ostojić, Jelena
author_facet Bajić, Dejana
Matijašević, Jovan
Andrijević, Ljiljana
Zarić, Bojan
Lalić-Popović, Mladena
Andrijević, Ilija
Todorović, Nemanja
Mihajlović, Andrea
Tapavički, Borislav
Ostojić, Jelena
author_sort Bajić, Dejana
collection PubMed
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and one group of patients has developed a severe form of COVID-19 pneumonia with an urgent need for hospitalization and intensive care unit (ICU) admission. The aim of our study was to evaluate the prognostic role of MDW, CRP, procalcitonin (PCT), and lactate in critically ill COVID-19 patients. The primary outcome of interest is the 28 day mortality of ICU patients with confirmed SARS-CoV-2 infection and sepsis (according to Sepsis 3 criteria with acute change in SOFA score ≥ 2 points). Patients were divided into two groups according to survival on the 28th day after admission to the ICU. Every group was divided into two subgroups (women and men). Nonparametric tests (Mann–Whitney) for variables age, PCT, lactate, and MDW were lower than alpha p < 0.05, so there was a significant difference between survived and deceased patients. The Chi-square test confirmed statistically significant higher values of MDW and lactate in the non-survivor group. We found a significant association between MDW, lactate, procalcitonin, and fatal outcome, higher values were reported in the deceased group.
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spelling pubmed-99175572023-02-11 Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients Bajić, Dejana Matijašević, Jovan Andrijević, Ljiljana Zarić, Bojan Lalić-Popović, Mladena Andrijević, Ilija Todorović, Nemanja Mihajlović, Andrea Tapavički, Borislav Ostojić, Jelena J Clin Med Article The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and one group of patients has developed a severe form of COVID-19 pneumonia with an urgent need for hospitalization and intensive care unit (ICU) admission. The aim of our study was to evaluate the prognostic role of MDW, CRP, procalcitonin (PCT), and lactate in critically ill COVID-19 patients. The primary outcome of interest is the 28 day mortality of ICU patients with confirmed SARS-CoV-2 infection and sepsis (according to Sepsis 3 criteria with acute change in SOFA score ≥ 2 points). Patients were divided into two groups according to survival on the 28th day after admission to the ICU. Every group was divided into two subgroups (women and men). Nonparametric tests (Mann–Whitney) for variables age, PCT, lactate, and MDW were lower than alpha p < 0.05, so there was a significant difference between survived and deceased patients. The Chi-square test confirmed statistically significant higher values of MDW and lactate in the non-survivor group. We found a significant association between MDW, lactate, procalcitonin, and fatal outcome, higher values were reported in the deceased group. MDPI 2023-02-02 /pmc/articles/PMC9917557/ /pubmed/36769843 http://dx.doi.org/10.3390/jcm12031197 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bajić, Dejana
Matijašević, Jovan
Andrijević, Ljiljana
Zarić, Bojan
Lalić-Popović, Mladena
Andrijević, Ilija
Todorović, Nemanja
Mihajlović, Andrea
Tapavički, Borislav
Ostojić, Jelena
Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title_full Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title_fullStr Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title_full_unstemmed Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title_short Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients
title_sort prognostic role of monocyte distribution width, crp, procalcitonin and lactate as sepsis biomarkers in critically ill covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917557/
https://www.ncbi.nlm.nih.gov/pubmed/36769843
http://dx.doi.org/10.3390/jcm12031197
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