The Response of Macrophages in Sepsis-Induced Acute Kidney Injury

Sepsis-induced acute kidney injury (SAKI) is common in critically ill patients and often leads to poor prognosis. At present, the pathogenesis of SAKI has not been fully clarified, and there is no effective treatment. Macrophages are immune cells that play an important role in the pathogenesis of SA...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Jiawei, Zhao, Shen, Duan, Meili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917612/
https://www.ncbi.nlm.nih.gov/pubmed/36769749
http://dx.doi.org/10.3390/jcm12031101
_version_ 1784886409430040576
author He, Jiawei
Zhao, Shen
Duan, Meili
author_facet He, Jiawei
Zhao, Shen
Duan, Meili
author_sort He, Jiawei
collection PubMed
description Sepsis-induced acute kidney injury (SAKI) is common in critically ill patients and often leads to poor prognosis. At present, the pathogenesis of SAKI has not been fully clarified, and there is no effective treatment. Macrophages are immune cells that play an important role in the pathogenesis of SAKI. The phenotype and role of macrophages can vary from early to later stages of SAKI. Elucidating the role of macrophages in SAKI will be beneficial to its diagnosis and treatment. This article reviews past studies describing the role of macrophages in SAKI, with the aim of identifying novel therapeutic targets.
format Online
Article
Text
id pubmed-9917612
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99176122023-02-11 The Response of Macrophages in Sepsis-Induced Acute Kidney Injury He, Jiawei Zhao, Shen Duan, Meili J Clin Med Review Sepsis-induced acute kidney injury (SAKI) is common in critically ill patients and often leads to poor prognosis. At present, the pathogenesis of SAKI has not been fully clarified, and there is no effective treatment. Macrophages are immune cells that play an important role in the pathogenesis of SAKI. The phenotype and role of macrophages can vary from early to later stages of SAKI. Elucidating the role of macrophages in SAKI will be beneficial to its diagnosis and treatment. This article reviews past studies describing the role of macrophages in SAKI, with the aim of identifying novel therapeutic targets. MDPI 2023-01-31 /pmc/articles/PMC9917612/ /pubmed/36769749 http://dx.doi.org/10.3390/jcm12031101 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Jiawei
Zhao, Shen
Duan, Meili
The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title_full The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title_fullStr The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title_full_unstemmed The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title_short The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
title_sort response of macrophages in sepsis-induced acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917612/
https://www.ncbi.nlm.nih.gov/pubmed/36769749
http://dx.doi.org/10.3390/jcm12031101
work_keys_str_mv AT hejiawei theresponseofmacrophagesinsepsisinducedacutekidneyinjury
AT zhaoshen theresponseofmacrophagesinsepsisinducedacutekidneyinjury
AT duanmeili theresponseofmacrophagesinsepsisinducedacutekidneyinjury
AT hejiawei responseofmacrophagesinsepsisinducedacutekidneyinjury
AT zhaoshen responseofmacrophagesinsepsisinducedacutekidneyinjury
AT duanmeili responseofmacrophagesinsepsisinducedacutekidneyinjury

Ejemplares similares