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Morbidity Associated with Chronic Hyponatremia
This article will discuss the consequences of chronic hyponatremia. In conditions such as cancer, heart failure, liver cirrhosis, or chronic kidney disease, the presence and magnitude of hypotonic hyponatremia are considered to reflect the severity of the underlying disease and are associated with i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917626/ https://www.ncbi.nlm.nih.gov/pubmed/36769626 http://dx.doi.org/10.3390/jcm12030978 |
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author | Decaux, Guy |
author_facet | Decaux, Guy |
author_sort | Decaux, Guy |
collection | PubMed |
description | This article will discuss the consequences of chronic hyponatremia. In conditions such as cancer, heart failure, liver cirrhosis, or chronic kidney disease, the presence and magnitude of hypotonic hyponatremia are considered to reflect the severity of the underlying disease and are associated with increased morbidity as well as mortality. Hyponatremia can be acute (<48 h) or chronic (>2–3 days). Chronic hyponatremia is associated with attention deficit, dizziness, tiredness, gait disturbance, falls, sarcopenia, bone fractures, osteoporosis, hypercalciuria (in the syndrome of inappropriate antidiuresis—SIADH), and kidney stones. In vitro studies have shown that cells grown in a low concentration of extracellular sodium have a greater proliferation rate and motility. Patients with chronic hyponatremia are more likely to develop cancer. We will not review the clinical consequences of respiratory arrest and osmotic demyelination syndrome (ODS) of the too-late or excessive treatment of hyponatremia. |
format | Online Article Text |
id | pubmed-9917626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99176262023-02-11 Morbidity Associated with Chronic Hyponatremia Decaux, Guy J Clin Med Opinion This article will discuss the consequences of chronic hyponatremia. In conditions such as cancer, heart failure, liver cirrhosis, or chronic kidney disease, the presence and magnitude of hypotonic hyponatremia are considered to reflect the severity of the underlying disease and are associated with increased morbidity as well as mortality. Hyponatremia can be acute (<48 h) or chronic (>2–3 days). Chronic hyponatremia is associated with attention deficit, dizziness, tiredness, gait disturbance, falls, sarcopenia, bone fractures, osteoporosis, hypercalciuria (in the syndrome of inappropriate antidiuresis—SIADH), and kidney stones. In vitro studies have shown that cells grown in a low concentration of extracellular sodium have a greater proliferation rate and motility. Patients with chronic hyponatremia are more likely to develop cancer. We will not review the clinical consequences of respiratory arrest and osmotic demyelination syndrome (ODS) of the too-late or excessive treatment of hyponatremia. MDPI 2023-01-27 /pmc/articles/PMC9917626/ /pubmed/36769626 http://dx.doi.org/10.3390/jcm12030978 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Decaux, Guy Morbidity Associated with Chronic Hyponatremia |
title | Morbidity Associated with Chronic Hyponatremia |
title_full | Morbidity Associated with Chronic Hyponatremia |
title_fullStr | Morbidity Associated with Chronic Hyponatremia |
title_full_unstemmed | Morbidity Associated with Chronic Hyponatremia |
title_short | Morbidity Associated with Chronic Hyponatremia |
title_sort | morbidity associated with chronic hyponatremia |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917626/ https://www.ncbi.nlm.nih.gov/pubmed/36769626 http://dx.doi.org/10.3390/jcm12030978 |
work_keys_str_mv | AT decauxguy morbidityassociatedwithchronichyponatremia |