Kidney Drug Transporters in Pharmacotherapy

The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug int...

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Detalles Bibliográficos
Autores principales: Łapczuk-Romańska, Joanna, Droździk, Maria, Oswald, Stefan, Droździk, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917665/
https://www.ncbi.nlm.nih.gov/pubmed/36769175
http://dx.doi.org/10.3390/ijms24032856
Descripción
Sumario:The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.

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